|
rs763751076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether carotid artery stiffness was increased in patients with untreated essential hypertension who are homozygous for the T allele of the M235T polymorphism of the angiotensinogen (AGT) gene and in mutant mice carrying three copies of the angiotensinogen (Agt) gene.
|
15201545 |
2004 |
|
rs762551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that SNP rs2228099 of ARNT is associated with an increased risk of EH (odds ratio=1.20 95% confidence interval: 1.01-1.44, P=0.043) in a dominant genetic model, whereas polymorphism rs762551 of CYP1A2 showed an association with a decreased risk of disease in a recessive genetic model (odds ratio=0.68, 95% confidence interval: 0.52-0.89, P=0.006).
|
27977510 |
2017 |
|
rs758980216
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The pedigrees of PLAH78 carrying the T5578C, PLAH84 carrying the C4467T, PLAH60 carrying the T5628C and PLAH118 carrying the C7492T mutation exhibited maternal transmission of essential hypertension.
|
26923935 |
2016 |
|
rs758801521
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations.
|
25732908 |
2016 |
|
rs758801521
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Constitutively activated GRK4 gene variants (R65L, A142V, and A486V), by themselves or by their interaction with other genes involved in blood pressure regulation, are associated with essential hypertension and/or salt-sensitive hypertension in several ethnic groups.
|
20153824 |
2010 |
|
rs7565062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our data showed that SNP rs756</span>5062 of SCN7A was significantly associated with EH and the allele T of rs7565062 or the related haplotype G-A-T will be a genetic risk factor for EH in the Northern Han Chinese population.
|
25393565 |
2015 |
|
rs755418013
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The pedigrees of PLAH78 carrying the T5578C, PLAH84 carrying the C4467T, PLAH60 carrying the T5628C and PLAH118 carrying the C7492T mutation exhibited maternal transmission of essential hypertension.
|
26923935 |
2016 |
|
rs7536827
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers.In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects from the TAMRISK cohort.
|
28151915 |
2017 |
|
rs752596535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study is to explore the association of OLR-1 polymorphism at position 501 in the open reading frame (G501C), with the susceptibility of essential hypertension.
|
18054331 |
2008 |
|
rs751141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs751141 allele gene polymorphism may be an independent protective factor against essential hypertension in the Han population.
|
25966114 |
2015 |
|
rs7444370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution of functional rs2301708 and rs7444370 polymorphisms within the KLHL3 gene was assessed through polymerase chain reaction (PCR) and restriction-fragment length polymorphism (RFLP).There was no significant difference in allelic and genotypic frequencies of KLHL3 rs2301708 between the EH and normotensive groups; however, the rs7444370 T allele and CT genotype in females was significantly associated with a protective effect against EH (P = .001, P = .002; P = .019, P = .052), and the haplotype CT of rs2301708 and rs7444370 among females in the EH group was less than in the normotensive group (P = .000; P = .007).The KLHL3 rs7444370 variant could be a protective factor in the pathogenesis of females' EH.
|
31096542 |
2019 |
|
rs743506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined whether the NOS3 tagSNPs rs3918226, rs3918188, and rs743506, and their haplotypes, affect the antihypertensive responses to enalapril in 101 patients with essential hypertension.
|
27060232 |
2016 |
|
rs73079108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs73079108 polymorphism in the 5' upstream region of C4BPA was associated with EH, and rs73079108‑A may be an independent predictor.
|
28627632 |
2017 |
|
rs7294
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the VKORC1 gene rs7294 polymorphism is important for the development of EH.
|
28281786 |
2017 |
|
rs7204044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations were found between the rs7204044 variant and EH in both the Mongolian and Han ethnic groups.
|
21644207 |
2011 |
|
rs713041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH).
|
22158110 |
2012 |
|
rs7119375
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The data suggest that APLNR rs7119375 and rs10501367 are associated with a decreased risk of essential hypertension in our Mexican-Mestizo studied group, but further studies are warranted.
|
27450650 |
2016 |
|
rs7119375
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two polymorphisms [rs3761581 (A/C) and T-1860C] in apelin gene and two [rs7119375 (G/A), rs10501367 (G/A)] in AGTRL1 gene were genotyped using the TaqMan assay among 969 patients diagnosed with essential hypertension and 980 age and sex-matched controls.
|
20485192 |
2010 |
|
rs7104980
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with EH in Chinese Han population.
|
22679278 |
2013 |
|
rs700518
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirmed that rs700518 and rs10046, as well as a haplotype constructed with rs1870049 and rs10046, in the human CYP19A1 gene can be used as genetic markers for gender-specific EH.
|
18274619 |
2008 |
|
rs699512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we hypothesized that BLVRA might be attributable to the variation of susceptibility to essential hypertension, and investigated single nucleotide polymorphism (SNP) rs699512 (Thr3Ala), the only common non-synonymous SNP within BLVRA, in population-based samples of 999 Kazak herdsmen from the villages in Xinjiang, China.
|
21721974 |
2011 |
|
rs699474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In Japanese subjects, no heterogeneity was found for rs699474, and no significant differences were observed between the EH and NT groups for the overall distribution of the genotypes or the alleles for each of the SNPs.
|
18971527 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease.
|
11731937 |
2002 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results support the linkage of essential hypertension to the angiotensinogen locus but do not indicate a specific role for the M235T variant.
|
9314412 |
1997 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether carotid artery stiffness was increased in patients with untreated essential hypertension who are homozygous for the T allele of the M235T polymorphism of the angiotensinogen (AGT) gene and in mutant mice carrying three copies of the angiotensinogen (Agt) gene.
|
15201545 |
2004 |