Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
BRAF
0.010 GeneticVariation BEFREE An Immune Suppression-associated EBV-positive Anaplastic Large Cell Lymphoma With a BRAF V600E Mutation. 30320628

2019
dbSNP: rs121913377
rs121913377
BRAF
0.010 GeneticVariation BEFREE An Immune Suppression-associated EBV-positive Anaplastic Large Cell Lymphoma With a BRAF V600E Mutation. 30320628

2019
dbSNP: rs863224686
rs863224686
TP53
0.010 GeneticVariation BEFREE Methotrexate significantly induced apoptosis in ALK inhibitor-resistant cells expressing the NPM-ALK mutant harboring the point mutation, G262R, and in ALCL patient-derived NPM-ALK-positive Ki-JK cells. 31654627

2019
dbSNP: rs1057519781
rs1057519781
ALK
0.010 GeneticVariation BEFREE ALCL xenografts selected <i>in vivo</i> showed recurrent N1178H (5/10 mice) and G1269A (4/10 mice) mutations. 30322862

2018
dbSNP: rs1226137439
rs1226137439
PIK3CG
0.010 GeneticVariation BEFREE ALCL xenografts selected <i>in vivo</i> showed recurrent N1178H (5/10 mice) and G1269A (4/10 mice) mutations. 30322862

2018
dbSNP: rs201227909
rs201227909
AKT1
0.010 GeneticVariation BEFREE ALCL xenografts selected <i>in vivo</i> showed recurrent N1178H (5/10 mice) and G1269A (4/10 mice) mutations. 30322862

2018
dbSNP: rs763830096
rs763830096
EGFR
0.010 GeneticVariation BEFREE ALCL xenografts selected <i>in vivo</i> showed recurrent N1178H (5/10 mice) and G1269A (4/10 mice) mutations. 30322862

2018
dbSNP: rs1057519859
rs1057519859
ALK
0.010 GeneticVariation BEFREE When OTX015 was associated with GANT61, a selective GLI1/2 inhibitor, C1156Y-resistant ALK ALCL growth was impaired.These findings support OTX015 clinical trials in refractory ALCL in combination with inhibitors of interleukin-2-inducible kinase or SHH/GLI1. 27793034

2016
dbSNP: rs113994089
rs113994089
ALK
0.010 GeneticVariation BEFREE These include novel variants with respect to ALK-fusion cancers, R1192P and T1151M, and with respect to ALCL, F1174L and I1171S. 27009859

2016
dbSNP: rs113994091
rs113994091
ALK
0.010 GeneticVariation BEFREE These include novel variants with respect to ALK-fusion cancers, R1192P and T1151M, and with respect to ALCL, F1174L and I1171S. 27009859

2016