Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893877
rs104893877
SNCA
0.020 GeneticVariation BEFREE Our results directly implicate tau as a mediator of specific human mutant A53T αS-mediated abnormalities related to deficits in hippocampal neurotransmission and suggest a mechanism for memory impairment that occurs as a consequence of synaptic dysfunction rather than synaptic or neuronal loss. 31168644

2019
dbSNP: rs63750424
rs63750424
MAPT
0.020 GeneticVariation BEFREE R406W patients often show a long course of disease with marked memory deficits. 29370822

2018
dbSNP: rs104893877
rs104893877
SNCA
0.020 GeneticVariation BEFREE A53T mice also exhibit spatial memory deficits at 6 and 12 months, as demonstrated by Y-maze performance. 23936403

2013
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.020 GeneticVariation BEFREE The COMT val(158)met polymorphism was associated with abstinence-related working memory deficits in two independent samples of smokers. 23828159

2013
dbSNP: rs281865071
rs281865071
CHRNB2
0.020 GeneticVariation BEFREE Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor. 18534914

2008
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.020 GeneticVariation BEFREE We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia. 17113268

2007
dbSNP: rs281865071
rs281865071
CHRNB2
0.020 GeneticVariation BEFREE The CHRNB2 mutation I312M is associated with epilepsy and distinct memory deficits. 15964197

2005
dbSNP: rs63750264
rs63750264
APP
0.020 GeneticVariation BEFREE The Tg-APP (Sw, V717F)/B6 mice at 11-14 months displayed decreased motor coordination, learning and memory deficits, and severely increased anxiety. 15114629

2004
dbSNP: rs63750424
rs63750424
MAPT
0.020 GeneticVariation BEFREE Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. 12368474

2002
dbSNP: rs63750264
rs63750264
APP
0.020 GeneticVariation BEFREE We previously showed that mice over-expressing a human mutated form of APP (APP(V717F)) display age-dependent recognition memory deficits associated with the progression of amyloid deposition. 10718322

2000
dbSNP: rs63751273
rs63751273
MAPT
0.030 GeneticVariation BEFREE Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit. 28634382

2017
dbSNP: rs63751273
rs63751273
MAPT
0.030 GeneticVariation BEFREE The present study was undertaken to examine whether lycopene or lycopene/vitamin E could exert protective effects on memory deficit and oxidative stress in tau transgenic mice expressing P301L mutation. 28269786

2017
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. 27521573

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. 27521573

2016
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. 23319002

2013
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. 23319002

2013
dbSNP: rs63751273
rs63751273
MAPT
0.030 GeneticVariation BEFREE Forebrain-specific over-expression of human tau(P301L), a mutation associated with frontotemporal dementia with parkinsonism linked to chromosome 17, in rTg4510 mice results in the formation of NFTs, learning and memory impairment and massive neuronal death. 22027994

2012
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction. 17392738

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE A previously reported valine to methionine substitution at amino-acid position 66 (BDNF Val66Met) seems to account for memory disturbance and hippocampal dysfunction. 17392738

2007
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR Mutation m.15923A>G in the MT-TT gene causes mild myopathy - case report of an adult-onset phenotype. 30236074

2018
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR CO2-sensitive tRNA modification associated with human mitochondrial disease. 29760464

2018
dbSNP: rs1977412
rs1977412
LOC105373166
C 0.700 GeneticVariation GWASCAT Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. 30514930

2018
dbSNP: rs2732260
rs2732260
FUT10
A 0.700 GeneticVariation GWASCAT Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. 29724592

2018
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR New mitochondrial DNA mutations in tRNA associated with three severe encephalopamyopathic phenotypes: neonatal, infantile, and childhood onset. 22638997

2012
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR Mitochondrial disorder associated with newborn cardiopulmonary arrest. 8511015

1993