|
rs8017304
|
|
|
0.830 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs2588809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs4351379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs4351376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs1064583
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
1093 patients with exudative AMD and 396 controls have been recruited and genotyped for the Y402H of CFH, rs10490924 of ARMS2 and T280M of the CX3CR1 gene.
|
21621535 |
2011 |
|
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
1093 patients with exudative AMD and 396 controls have been recruited and genotyped for the Y402H of CFH, rs10490924 of ARMS2 and T280M of the CX3CR1 gene.
|
21621535 |
2011 |
|
rs752160946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
2633C>A (CC+CA) genotype, 5646G>A and 6389T>A polymorphisms of ABCA4 gene and smoking are susceptible factors for AMD, and the interactions of ABCA4 polymorphisms with smoking increased the risk of AMD.
|
26261643 |
2015 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Age-related macular degeneration is a leading form of blindness in Western countries and is associated with a common SNP (rs 1061170/Y402H) in the Factor H gene, which encodes the two complement inhibitors Factor H and FHL1.
|
21930971 |
2011 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
AMD individuals who had at least one copy of the C allele of rs1061170 had an increased risk of disease compared with cases with the T allele.
|
25612476 |
2016 |
|
rs148957473
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H244R VSX1 is associated with selective cone ON bipolar cell dysfunction and macular degeneration in a PPCD family.
|
16384943 |
2006 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Y402H polymorphism which has been suggested to be a major risk factor of AMD in Caucasians was found to be only marginally associated with exudative AMD with low frequency, whereas three adjacent SNPs in the CFH gene were significantly associated with AMD in Koreans.
|
18223247 |
2008 |
|
rs2736911
|
|
|
0.060 |
GeneticVariation |
BEFREE |
R38X variant of ARMS2 seems to be protective from wet ARMD.
|
22293892 |
2012 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs1061170 might be associated with treatment response of neovascular AMD, especially for the anti-VEGF agents.
|
22905135 |
2012 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Y402H polymorphism in complement factor H and age-related macular degeneration in the Tunisian population.
|
23306536 |
2013 |
|
rs757785149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R53C segregates perfectly with AMD in 11 cases (heterozygous) and 1 elderly control (reference allele) (LOD = 5.07, P = 6.7 × 10(-7)).
|
24847005 |
2014 |
|
rs1999930
|
|
|
0.820 |
GeneticVariation |
BEFREE |
rs1999930 and rs4711751 have recently been identified as novel variants associated with advanced age-related macular degeneration (AMD) in populations of European ancestry.
|
25228097 |
2014 |
|
rs1800553
|
|
|
0.060 |
GeneticVariation |
BEFREE |
G1961E has been associated previously, at a statistically significant level in the heterozygous state, with age-related macular degeneration (AMD).
|
9973280 |
1999 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A 6.7-fold increased odds of AMD (95% CI, 1.6-28.2) was observed among women with deficient vitamin D status (25[OH]D <12 ng/mL) and 2 risk alleles for CFH Y402H (SI for additive interaction, 1.4; 95% CI, 1.1-1.7; P for multiplicative interaction = .25).
|
26312598 |
2015 |
|
rs3812153
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A Met299Val variant in the elongation of very long chain fatty acids-like 4 (ELOVL4) gene was significantly associated with ARM in the case-control allele (P=0.001), case-control genotype (P=0.001) and case-control family (P<0.0001) tests.
|
15930014 |
2005 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A Tyr402His variant in exon 9 in the complement factor H (CFH) gene was also significantly associated with ARM in the case-control allele (P<0.0001), case-control genotype (P<0.0001) and case-control family (P<0.0001) tests.
|
15930014 |
2005 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A combination of elevated CRP and the CC (Y402H) genotype resulted in a super-additivity of the risks, with odds ratios of 19.3 (95% CI, 2.8-134) for late AMD, and 6.8 (95% CI, 1.2-38.8) for AMD progression, with the attributable proportion of risk owing to CRP-CFH interaction calculated at 26% for prevalent late AMD and 22% for AMD progression.
|
20605213 |
2010 |
|
rs1061170
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A common polymorphism in the complement factor H gene (rs1061170, Y402H) is associated with a high risk of age-related macular degeneration (AMD).
|
23596508 |
2013 |
|
rs3736265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs).
|
23335958 |
2013 |
|
rs3774923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs).
|
23335958 |
2013 |