|
rs1416313401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From analysis of naturally occurring pVHL mutants, it seems that only point mutations such as pVHL(Y98H) and pVHL(Y112H) (that predispose to haemangioblastoma and phaeochromocytoma, but not to renal cell carcinoma) disrupt pVHL's microtubule-stabilizing function.
|
12510195 |
2003 |
|
rs5030809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From analysis of naturally occurring pVHL mutants, it seems that only point mutations such as pVHL(Y98H) and pVHL(Y112H) (that predispose to haemangioblastoma and phaeochromocytoma, but not to renal cell carcinoma) disrupt pVHL's microtubule-stabilizing function.
|
12510195 |
2003 |
|
rs2231142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers with the C/C genotype of the BCRP C421A polymorphism are at risk of developing nonpapillary RCC.
|
15906349 |
2005 |
|
rs141683432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, methylation-specific PCR analysis revealed promoter region methylation in 30% (19 of 64) of clear cell RCC and 40% (15 of 38) of papillary RCC, whereas mutation analysis (in 39 RCC cell lines and primary tumors) revealed a missense substitution (P111S) in one RCC cell line.
|
15930277 |
2005 |
|
rs17576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present results suggest that MMP9 R279Q polymorphism has influence on the malignant potential of RCC.
|
16466849 |
2006 |
|
rs758272654
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show that besides tumor stage, lymph node status, and tumor grade, the GNAS1 T393C status is a novel independent host factor for disease progression in patients with clear cell renal cell carcinoma and provides further evidence for the T393C polymorphism as a general prognostic tumor marker.
|
16467086 |
2006 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the frequency of 399Gln variant at XRCC1 Arg399Gln was significantly higher in RCC cases than in controls (OR=2.83, 95%CI=1.24-6.49, P=0.01).
|
16510122 |
2006 |
|
rs937475913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the frequency of 399Gln variant at XRCC1 Arg399Gln was significantly higher in RCC cases than in controls (OR=2.83, 95%CI=1.24-6.49, P=0.01).
|
16510122 |
2006 |
|
rs1064794272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous patients with the N131K or N131T mutation in pVHL developed VHLD type 2B with RCC or VHLD type 1 without PHE, respectively.
|
17001110 |
2006 |
|
rs2273535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This first analysis of the STK15 T91A SNP in RCC patients revealed no correlation between a certain allelic variant and an increased risk for RCC.
|
17143471 |
2007 |
|
rs1222213359
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We investigated the associations of three polymorphisms (-2578C/A, -1154G/A, and -634C/G) in the VEGF gene with the clinicopathologic parameters and survival of 213 patients with RCC.
|
17287073 |
2007 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
rs1353702185
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
rs1057520001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
rs886039484
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC.
|
17634539 |
2007 |
|
rs1801133
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR = 1.44; 95% CI: 1.17-1.77; p = 0.001).
|
18098291 |
2008 |
|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In individual single nucleotide polymorphism analysis, after adjustment for multiple comparisons, a significantly decreased RCC risk was observed for the heterozygous genotype of XPD Asp312Asn [odds ratio (OR) = 0.62; 95% confidence interval (CI): 0.43-0.90] and for the heterozygous and homozygous variant genotypes combined in a dominant model (OR = 0.64; 95% CI: 0.46-0.89).
|
18711149 |
2008 |
|
rs11549465
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
|
rs11549467
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
|
rs12553173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CA9 rs12553173 and CAIX are independent prognostic factors of overall survival and complementary for predicting the prognosis of metastatic clear cell renal cell carcinoma.
|
19539328 |
2009 |
|
rs1801275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study is aimed at analyzing the presence and significance of the interleukin-4-receptor alpha Ile50Val and Gln576Arg polymorphisms in a group of RCC patients from South India.
|
19548368 |
2009 |
|
rs12953717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped 14 single nucleotide polymorphisms (SNPs) in 6 genes. including Dickkopf 2 (DKK2) (reference SNP identification number 17037102 [rs17037102], rs419558, and rs447372), DKK3 (rs3206824, rs11022095, rs1472189, rs7396187, and rs2291599), DKK4 (rs2073664), secreted frizzled-related protein 4 (sFRP4) (rs1802073 and rs1802074), mothers against decapentaplegic homolog (SMAD) family member 7 or SMAD7 (rs12953717), and disheveled associated activator of morphogenesis 2 or DAAM2 (rs6937133 and rs2504106) using polymerase chain reaction-restriction fragment length polymorphism analysis and direct sequencing in the patients with RCC and in the healthy, age-matched control group.
|
19562778 |
2009 |
|
rs17037102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To the authors' knowledge, this is the first report documenting that DKK3 polymorphisms are associated with RCC and that the DKK2 rs17037102 polymorphism may be a predictor for survival in patients with RCC after radical nephrectomy.
|
19562778 |
2009 |