|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
<b>Results:</b> Significant associations with neuroblastoma risk were found for four (rs110419, rs4758051, rs10840002, and rs2168101) out of the five polymorphisms.
|
30406033 |
2018 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We also confirmed that rs6939340 A>G (G versus A: OR=1.30, 95% CI=1.13-1.50) and rs110419 G>A (A versus G: OR=1.37, 95% CI=1.19-1.58) were associated with increased neur</span>oblastoma risk for all subjects.
|
29024823 |
2017 |
|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A major haplotype, ATC, containing rs204926, rs110420, and rs110419, conferred a significant increase in risk for NB (OR = 1.82, 95% CI: 1.41-2.36, adjusted P < 0.001).
|
26030754 |
2015 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Two (P117L; M146L) familial Alzheimer's disease (FAD)-causing presenilin-1 (PS1) mutations have been tested fortheir effect in stably transfected mouse neuroblastoma (N2a) cell lines.
|
10400232 |
1999 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we report that the expression of FAD-linked PS1 M146V mutant affects store-operated calcium channel activity (Isoc) in human neuroblastoma SK-N-SH cells.
|
23624206 |
2013 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The influence of PS1 mutations on the generation of endogenous intracellular amyloid beta-protein (A beta) species was assessed using a highly sensitive immunoblotting technique with inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated PS1 (M146L or delta exon 10).
|
9751187 |
1998 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To elucidate the role of presenilin-1 in the Alzheimer's disease pathology, we tested two such mutations (P117L and M146L) for their effect in stably transfected mouse neuroblastoma cell lines.
|
11311782 |
2001 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate the pathogenic mechanism of PS1 mutations linked to FAD, we established inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated PS1(M146L or deltaexon 10) under the control of the Lac repressor.
|
10360683 |
1999 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In a combination analysis using Southern and Northern Chinese populations, we found that those carrying the rs110419 G, rs4758051 A or rs10840002 G allele were at decreased neuroblastoma risk, and this finding was supported by a false-positive report probability analysis.
|
29029458 |
2017 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility.
|
27009839 |
2016 |
|
rs121912431
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Expression of mutant SOD1 (G37R) resulted in a time and dose-related death of differentiated neuroblastoma cells.
|
12067230 |
2002 |
|
rs121912431
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Mouse neuroblastoma Neuro-2a cells were transfected with human wild-type or mutated (G37R, G93A) Cu,Zn-SOD.
|
15456693 |
2005 |
|
rs121912431
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previously, we reported that overexpression of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD or SOD2) attenuates cytotoxicity induced by expression of the G37R-SOD1 mutant in a human neuroblastoma cell culture model of ALS.
|
17394531 |
2007 |
|
rs121912431
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Here, we show that stable overexpression of mutant human SOD1 (G37R) - but not wild-type SOD1 (wt-SOD1) - in mouse neuroblastoma cells (N2a) results in morphological abnormalities of mitochondria accompanied by several dysfunctions.
|
21388680 |
2011 |
|
rs1386984902
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present study evaluates the impact of neurosteroids belonging to the sex hormone family (progesterone, estradiol, estrone, testosterone, 3α-androstanediol) on mitochondrial dysfunction in cellular models of AD: human neuroblastoma cells (SH-SY5Y) stably transfected with constructs encoding (1) the human amyloid precursor protein (APP) resulting in overexpression of APP and Aβ, (2) wild-type tau (wtTau), and (3) mutant tau (P301L), that induces abnormal tau hyperphosphorylation.
|
26198711 |
2016 |
|
rs1386984902
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study, we aimed to characterize the link between ER stress and bioenergetics defects under normal condition (human SH-SY5Y neuroblastoma cells: control cells) or under pathological AD condition [SH-SY5Y cells overexpressing either the human amyloid precursor protein (APP) or mutant tau (P301L)].
|
30683981 |
2019 |
|
rs1386984902
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present study aimed to evaluate the impact of the new TSPO ligands on mitochondrial dysfunction in a cellular model of AD-related tauopathy (human neuroblastoma cells SH-SY5Y stably overexpressing the P301L-mutant Tau) presenting mitochondrial impairments, including a decreased ATP synthesis and mitochondrial membrane potential, as well as a decrease in pregnenolone synthesis compared to control cells.
|
31536662 |
2020 |
|
rs1386984902
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To understand which processes are disrupted by Abeta42 in the presence of tau aggregates, we applied comparative proteomics to Abeta42-treated P301L tau-expressing neuroblastoma cells and the amygdala of P301L tau transgenic mice stereotaxically injected with Abeta42.
|
17111439 |
2006 |
|
rs204938
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In contrast, the rs204938 polymorphism showed a positive association with NB susceptibility in allele genetic models.
|
31830377 |
2020 |
|
rs204938
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In this work, we used Taqman methodology to genotype four <i>LMO1</i> polymorphisms (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in 118 neuroblastoma cases and 281 controls from Northern China.
|
29029458 |
2017 |
|
rs204938
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility.
|
27009839 |
2016 |
|
rs204938
|
|
|
0.040 |
GeneticVariation |
BEFREE |
<b>Objective:</b> We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified <i>LMO1</i> variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
|
30406033 |
2018 |
|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |