|
rs2670660
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results suggest that NLRP1 rs2670660 and rs6502867 polymorphisms may be genetic risk factors for susceptibility to and progression of GV.
|
23773036 |
2013 |
|
rs2670660
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that two SNPs in the NALP1 extended promoter region, rs1008588 and rs2670660 were significantly associated with generalized vitiligo in our cohort of Arab vitiligo patients, and several other SNPs in the NALP1 region were at the margin of significant association.
|
20574744 |
2010 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to test genetic association of the PTPN22 1858C>T variant and generalized vitiligo in a Romanian case-control cohort.
|
18426414 |
2008 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The PTPN22 1858T allele of SNP rs2476601 is significantly associated both with generalized vitiligo and with an expanded autoimmunity phenotype.
|
18200060 |
2008 |
|
rs2670660
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study confirms genetic association of generalized vitiligo with variation in NALP1, which contains at least two independent risk signals, one tagged by SNP rs6502867 and another tagged by SNPs rs2670660 and rs8182352.
|
17637824 |
2007 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The results indicate that the LYP missense R620W polymorphism may have an influence on the development of generalised vitiligo and provide further evidence for autoimmunity as an aetiological factor with respect to this disease.
|
16015369 |
2005 |
|
rs6502867
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that NLRP1 rs2670660 and rs6502867 polymorphisms may be genetic risk factors for susceptibility to and progression of GV.
|
23773036 |
2013 |
|
rs10932037
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The first study, of SNPs rs1863800, rs231806, rs231775, rs3087243, rs11571302, rs11571297, and rs10932037, showed no allelic, genotypic, or haplotypic association with generalized vitiligo.
|
19175525 |
2009 |
|
rs10932037
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Examination of five SNPs in the CTLA4 gene (rs1863800, rs231775, rs3087243, rs11571302, rs11571297, rs10932037) in the same 126 families yielded no evidence of allelic or genotypic association with either generalized vitiligo or the expanded autoimmune phenotype.
|
18200060 |
2008 |
|
rs6502867
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study confirms genetic association of generalized vitiligo with variation in NALP1, which contains at least two independent risk signals, one tagged by SNP rs6502867 and another tagged by SNPs rs2670660 and rs8182352.
|
17637824 |
2007 |
|
rs11966200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study suggested that the underlying risk causal allele tagged by SNP rs11966200 might not only play important roles in the development of vitiligo, but also contribute to the diverse clinical characteristics of generalized vitiligo at least in Chinese Han population.
|
23516070 |
2013 |
|
rs12150220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12150220 polymorphism was found have a marginal association with GV.
|
23773036 |
2013 |
|
rs2430561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of present study was to determine whether intron 1 +874A/T (rs2430561) and CA microsatellite (rs3138557) polymorphisms in IFNG are associated with generalized vitiligo (GV) susceptibility and expression of IFNG and intercellular adhesion molecule-1 (ICAM1) affects the disease onset and progression.
|
23777204 |
2013 |
|
rs3138557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of present study was to determine whether intron 1 +874A/T (rs2430561) and CA microsatellite (rs3138557) polymorphisms in IFNG are associated with generalized vitiligo (GV) susceptibility and expression of IFNG and intercellular adhesion molecule-1 (ICAM1) affects the disease onset and progression.
|
23777204 |
2013 |
|
rs9468925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the association between rs9468925 polymorphism within MHC and the clinical features of generalized vitiligo.
|
21951294 |
2012 |
|
rs12992492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of GV with CTLA4 (rs12992492, P=5.9E-05, OR=1.20; meta-P for rs231775=1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases.
|
21085187 |
2011 |
|
rs7758128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a quantitative trait locus for vitiligo age of onset in the major histocompatibility complex (MHC) class II region, located near c6orf10-BTNL2 (rs7758128; P=8.14 × 10(-11)), a region that is also associated with generalized vitiligo susceptibility.
|
21326295 |
2011 |
|
rs1008588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that two SNPs in the NALP1 extended promoter region, rs1008588 and rs2670660 were significantly associated with generalized vitiligo in our cohort of Arab vitiligo patients, and several other SNPs in the NALP1 region were at the margin of significant association.
|
20574744 |
2010 |
|
rs13208776
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The region of association contains only one gene, SMOC2, within which SNP rs13208776 attained genome-wide significance for association with generalized vitiligo (P=8.51x10(-8)) at odds ratio 7.445 (95% confidence interval=3.56-15.53) for the high-risk allele and population attributable risk 28.00.
|
19890347 |
2010 |
|
rs17008723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).
|
20526340 |
2010 |
|
rs6902119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).
|
20526340 |
2010 |
|
rs8182352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study confirms genetic association of generalized vitiligo with variation in NALP1, which contains at least two independent risk signals, one tagged by SNP rs6502867 and another tagged by SNPs rs2670660 and rs8182352.
|
17637824 |
2007 |