|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also examined the association of CHRNA5 D398N polymorphism with lung cancer risk and with CHRNA5 mRNA levels in the normal lung.
|
19223495 |
2009 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used urinary biomarkers to test whether two linked lung cancer risk variants in CHRNA3 (rs1051730) and CHRNA5 (rs16969968) are associated with intensity of smoking and exposure to a tobacco-specific carcinogenic nitrosamine per cigarette dose.
|
19010884 |
2008 |
|
rs588765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, rs588765-rs16969968 may be a genetic marker to lung cancer risk, even among never-smokers.
|
26282330 |
2015 |
|
rs3829787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the polymorphisms (rs3829787 and rs3841324) statistically influenced the risk of developing lung cancer.
|
23011884 |
2013 |
|
rs503464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the heterozygous genotype c.-166T>A at rs503464 of CHRNA5 may be associated with reduced risk of lung cancer, thus representing a susceptibility allele in Chinese individuals.
|
23314339 |
2013 |
|
rs667282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we did not observe a significant association of each genotype of the two SNPs with risk of gastric cancer (TT/CT vs. CC: adjusted OR = 1.12,95 % CI = 0.86-1.45; p = 0.401 for rs667282 and GG/TG vs. TT: adjusted OR = 1.13,95 % CI = 0.90-1.43; p = 0.300 for rs3743073).The results of our study indicated that these two SNPs at the 15q25 locus did not modify gastric cancer risk and the reported risk SNP at 15q25 may be specific to lung cancer.
|
23576140 |
2013 |
|
rs11637635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs17408276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs17486278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk.
|
20587604 |
2010 |
|
rs481134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer.
|
20395203 |
2010 |