|
rs56391007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that MET(T1010I) sequence alteration is relatively frequent in differentiated thyroid carcinoma.
|
15767811 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DTC was present in half of the cases.BRAF V600E mutation was identified in nine of 36 (25%) ATCs; seven cases had identical mutations in both the ATC and DTC components.
|
17989125 |
2008 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DTC was present in half of the cases.BRAF V600E mutation was identified in nine of 36 (25%) ATCs; seven cases had identical mutations in both the ATC and DTC components.
|
17989125 |
2008 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Multivariate analysis demonstrated an increased risk of DTC for the Arg194Trp heterozygous polymorphic (CT) genotype (odds ratio [OR]: 1.4, 95% confidence interval [CI]: 0.9-2.1).
|
19191745 |
2009 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Multivariate analysis demonstrated a decreased risk of DTC for the Arg399Gln homozygous polymorphic (AA) genotype (OR: 0.5, 95% CI: 0.3-0.8) and the polymorphic (A) allele (OR: 0.7, 95% CI: 0.5-1.0).
|
19191745 |
2009 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).
|
19356676 |
2009 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).
|
19356676 |
2009 |
|
rs2070593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 6 tSNPs (rs3763013, rs8177412, rs3805435, rs3828599, rs3792796, and rs2070593) of GPX3 were genotyped in Chinese DTC cases (n = 268) and controls (n = 378).
|
19375609 |
2009 |
|
rs3805435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
|
19375609 |
2009 |
|
rs3828599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
|
19375609 |
2009 |
|
rs8177412
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.
|
19375609 |
2009 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The MTHFR 677C→T homozygous variant allele may be associated with increased risk of DTC.
|
21050834 |
2011 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The two SNPs that map at 8q24, rs6983267 and rs1447295, and the two TRHR polymorphisms showed no association with DTC.
|
21476894 |
2011 |
|
rs6983267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The two SNPs that map at 8q24, rs6983267 and rs1447295, and the two TRHR polymorphisms showed no association with DTC.
|
21476894 |
2011 |
|
rs3764340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidences that the polymorphism Pro-282-Ala within the tumor suppressor gene WWOX is a new risk factor for differentiated thyroid carcinoma.
|
21520031 |
2011 |
|
rs12885300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The type 2 deiodinase ORFa-Gly3Asp polymorphism (rs12885300) influences the set point of the hypothalamus-pituitary-thyroid axis in patients treated for differentiated thyroid carcinoma.
|
21715540 |
2011 |
|
rs2132572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IGFBP-3 rs2132572 GA/AA genotypes were associated with a decreased risk of DTC (adjusted OR = 0.6, 95% CI: 0.4-0.9), particularly multifocal DTC (adjusted OR = 0.3, 95% CI: 0.1-0.7).
|
22415807 |
2012 |
|
rs1800057
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under a dominant model of inheritance, the G allele of ATM rs189037 exhibited a protective effect against DTC (adjusted OR = 0.8; 95% CI, 0.6-1.0; P = 0.04), and the G allele of rs1800057 was associated with increased risk of DTC (adjusted OR = 1.9; 95% CI, 1.1-3.1; P = 0.02).
|
22438227 |
2012 |
|
rs189037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under a dominant model of inheritance, the G allele of ATM rs189037 exhibited a protective effect against DTC (adjusted OR = 0.8; 95% CI, 0.6-1.0; P = 0.04), and the G allele of rs1800057 was associated with increased risk of DTC (adjusted OR = 1.9; 95% CI, 1.1-3.1; P = 0.02).
|
22438227 |
2012 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of this study were to evaluate the utility of US-guided FNAB in the diagnostic assessment of nodules with or without clinical/US features suggestive for malignancy and to investigate the additional contribution of BRAF V600E mutation analysis in the detection of differentiated thyroid cancer.
|
22535974 |
2012 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of this study were to evaluate the utility of US-guided FNAB in the diagnostic assessment of nodules with or without clinical/US features suggestive for malignancy and to investigate the additional contribution of BRAF V600E mutation analysis in the detection of differentiated thyroid cancer.
|
22535974 |
2012 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Increased T-allele frequency of 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene in differentiated thyroid carcinoma.
|
22536880 |
2012 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs10877012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs12794714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |