|
rs10136427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only the associations between rs10136427 and rs7267944 and DTC risk were replicated in the Polish and the Spanish populations with little evidence of population heterogeneity (GWAS and all replications combined, OR = 1.30, P = 9.30 × 10(-7) and OR = 1.32, P = 1.34 × 10(-8), respectively).
|
25029422 |
2014 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significant association of TP53 Arg72Pro polymorphism in susceptibility to differentiated thyroid cancer.
|
25835179 |
2015 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, in this study, we analyzed the associations of intron 3 Ins16bp and exon 4 Arg72Pro polymorphisms, as well as their combined genotypes and haplotypes with the risk of differentiated thyroid carcinoma in Iranian-Azeri patients.
|
25410025 |
2015 |
|
rs1057519695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one.
|
24468978 |
2014 |
|
rs1057519834
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one.
|
24468978 |
2014 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs10808556
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphisms rs10808556 and rs1447295 showed an association with the risk of DTC (the strongest were the heterozygotes with OR, 1.38; 95% CI, 1.13-1.68 and OR, 1.35; 95% CI, 1.02-1.78, respectively), but, overall, they were unable to reach the statistically significant threshold following Bonferroni's correction.
|
24008490 |
2013 |
|
rs10877012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
rs11175834
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer.
|
28703219 |
2017 |
|
rs11214077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our current study shows that SDHD-G12S and -H50R variants cause down-regulation of autophagy, demonstrating a role for SDHD in autophagy-associated pathogenesis of differentiated thyroid cancer.
|
28164237 |
2017 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, in this study, we analyzed the associations of intron 3 Ins16bp and exon 4 Arg72Pro polymorphisms, as well as their combined genotypes and haplotypes with the risk of differentiated thyroid carcinoma in Iranian-Azeri patients.
|
25410025 |
2015 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significant association of TP53 Arg72Pro polymorphism in susceptibility to differentiated thyroid cancer.
|
25835179 |
2015 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E Status and Stimulated Thyroglobulin at Ablation Time Increase Prognostic Value of American Thyroid Association Classification Systems for Persistent Disease in Differentiated Thyroid Carcinoma.
|
31093278 |
2019 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that BRAF(V600E)-mutated DTCs are significantly more (18)F-FDG-avid than BRAF-WT tumors.
|
25814520 |
2015 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither the presence of V600E BRAF mutations nor that of a well-differentiated thyroid carcinoma changed the outcome or disease-free survival.
|
24777145 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DTC was present in half of the cases.BRAF V600E mutation was identified in nine of 36 (25%) ATCs; seven cases had identical mutations in both the ATC and DTC components.
|
17989125 |
2008 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).
|
19356676 |
2009 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results show a high rate and a strong prognostic role of the classical BRAF (V600E) mutation and also suggest a common occurrence of non-hot spot mutations in adult DTC from this highly inbred population.
|
27387551 |
2016 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study investigated the role of molecular studies in preoperative diagnosis of DTC and</span> the association of p.V600E mutation with prognostic factors.
|
24468978 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found TERT promoter mutations in 0.0% (0/179) of benign thyroid nodules and 7.0% (9/129) of thyroid nodules of differentiated thyroid cancer, representing a 100% diagnostic specificity and 7.0% sensitivity, with the latter rising to 38.0% (49/129) when combined with BRAF V600E testing.
|
25121551 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genetic duet of BRAF V600E/RAS and TERT promoter mutations is a most robust prognostic genetic pattern for poor prognosis of differentiated thyroid cancer.
|
30717896 |
2019 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of this study were to evaluate the utility of US-guided FNAB in the diagnostic assessment of nodules with or without clinical/US features suggestive for malignancy and to investigate the additional contribution of BRAF V600E mutation analysis in the detection of differentiated thyroid cancer.
|
22535974 |
2012 |
|
rs11554290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one.
|
24468978 |
2014 |
|
rs116909374
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among Europeans, we found that the two SNPs previously reported at 9q22 were not independently associated to DTC and that rs965513 was the predominant signal; at 14q13, we showed that the haplotype rs944289[C]-rs116909374[C]-rs999460[T] was significantly associated with DTC risk and that the association with rs116909374 differed by smoking status (p-interaction = 0.03).
|
26991144 |
2016 |
|
rs116909374
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Five germline genetic variants (rs116909374, rs965513, rs944289, rs966423, and rs2439302) have been associated in genome-wide association studies (GWAS) with increased risk of differentiated thyroid cancer (DTC), but their role in mortality of patients has not been established.
|
26490305 |
2016 |