|
rs619586
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that miR-214 inhibited MALAT1 expression by directly binding to the G allele of MALAT1 rs619586 polymorphism, thus inhibiting CTNNB1 expression and promoting cell proliferation in the pathogenesis of DTC.
|
31456244 |
2020 |
|
rs371428527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found 3.37% and 2.45% (includes Q214H, a novel <i>PTEN</i> mutation) in GPCR-mediated PI3K pathway of pediatric and adult DTCs, respectively.
|
31289610 |
2019 |
|
rs4946936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> Patients with DTC tended to carry more often allele C in <i>FOXO3a</i> rs4946936 in comparison to HC (p<sub>corrected</sub> = p<sub>c</sub> = 0.08).
|
30271381 |
2018 |
|
rs768827923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, our study revealed that the c.1924G>T hot-spot mutation in <i>RasGRP3</i> is a more frequent genetic alteration in metastases of RAI-refractory differentiated thyroid cancer.
|
30323976 |
2018 |
|
rs9400239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> The SNP's <i>FOXO3a</i> rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC).
|
30271381 |
2018 |
|
rs11214077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our current study shows that SDHD-G12S and -H50R variants cause down-regulation of autophagy, demonstrating a role for SDHD in autophagy-associated pathogenesis of differentiated thyroid cancer.
|
28164237 |
2017 |
|
rs1799939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis showed that concomitant thyroid benign diseases were less likely to occur in DTC subjects with the rs1799939 AG or AG plus AA genotypes (odds ratio (OR) = 1.93 and 1.88, P = 0.009 and 0.011, respectively).
|
29131865 |
2017 |
|
rs1800860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concerning the aggressive features of DTC, higher level of N stage was more likely to occur in subjects carrying the wild-type genotypes at rs1800860 site (for dominant model: OR = 0.48, P = 0.008).
|
29131865 |
2017 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2910164 variant in <i>MIR146A</i> is significantly associated with DTC, but is not significantly associated with BC in this cohort.
|
28899898 |
2017 |
|
rs34677591
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our current study shows that SDHD-G12S and -H50R variants cause down-regulation of autophagy, demonstrating a role for SDHD in autophagy-associated pathogenesis of differentiated thyroid cancer.
|
28164237 |
2017 |
|
rs16962916
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, rs16962916 and rs3136166 in ERCC4, and rs17739370 and rs7689099 in NEIL3) was associated with the risk of DTC when the correction of multiple testing was applied.
|
27062014 |
2016 |
|
rs17739370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, rs16962916 and rs3136166 in ERCC4, and rs17739370 and rs7689099 in NEIL3) was associated with the risk of DTC when the correction of multiple testing was applied.
|
27062014 |
2016 |
|
rs2439302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five germline genetic variants (rs116909374, rs965513, rs944289, rs966423, and rs2439302) have been associated in genome-wide association studies (GWAS) with increased risk of differentiated thyroid cancer (DTC), but their role in mortality of patients has not been established.
|
26490305 |
2016 |
|
rs2480258
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of four haplotype tagging SNPs (ht-SNPs) within the locus in a discovery case-control study (N = 350/350) indicated an association between rs2480258 and DTC risk.
|
26783003 |
2016 |
|
rs3136166
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, rs16962916 and rs3136166 in ERCC4, and rs17739370 and rs7689099 in NEIL3) was associated with the risk of DTC when the correction of multiple testing was applied.
|
27062014 |
2016 |
|
rs7689099
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although a positive signal was detected at the nominal level of 0.05 for rs7689099 (encoding for an aminoacid change proline to arginine at codon 117 within NEIL3), none of the considered SNPs (i.e. rs7990340 and rs690860 within RFC3, rs3744767 and rs1131636 within RPA1, rs16962916 and rs3136166 in ERCC4, and rs17739370 and rs7689099 in NEIL3) was associated with the risk of DTC when the correction of multiple testing was applied.
|
27062014 |
2016 |
|
rs966423
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of the rs966423-TT genotype was associated with a significant increase in overall mortality of patients with DTC.
|
26490305 |
2016 |
|
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, no association between DTC and the coding SNP D1853N (rs1801516) in ATM (OR per A Allele = 1.1, 95% CI: 0.7-1.7) was seen.
|
25879635 |
2015 |
|
rs71369530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests.
|
25879635 |
2015 |
|
rs10136427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only the associations between rs10136427 and rs7267944 and DTC risk were replicated in the Polish and the Spanish populations with little evidence of population heterogeneity (GWAS and all replications combined, OR = 1.30, P = 9.30 × 10(-7) and OR = 1.32, P = 1.34 × 10(-8), respectively).
|
25029422 |
2014 |
|
rs1057519695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one.
|
24468978 |
2014 |
|
rs1057519834
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one.
|
24468978 |
2014 |
|
rs11554290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one.
|
24468978 |
2014 |
|
rs1220597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A possible role in DTC susceptibility in the Italian populations was also found for rs13184587 (ARSB) (P = 8.54 × 10(-6)) and rs1220597 (SPATA13) (P = 3.25 × 10(-6)).
|
25029422 |
2014 |
|
rs1302723597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the potential effect of some HR repair gene polymorphisms with differentiated thyroid carcinoma (DTC), we assessed Rad51 (135G>C), Rad52 (2259C>T), XRCC2 (R188H) and XRCC3 (T241M) polymorphisms in Iranian DTC patients and cancer-free controls.
|
24377596 |
2014 |