|
rs1057518797
|
|
TAGGACG |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1556446493
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs730882222
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs754279998
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs770084716
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs699
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failure. End-Stage Renal Disease Study Group.
|
10916074 |
2000 |
|
rs1267969615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failure. End-Stage Renal Disease Study Group.
|
10916074 |
2000 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In this case-control, cross-sectional study the frequency of the MTHFR 677C --> T and the 1298A --> C polymorphism was compared between patients with hypertension-related chronic renal failure (n = 90), patients with essential hypertension without kidney injury (n = 90), and healthy individuals (n = 90) who were matched for age and gender.
|
16280279 |
2005 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this case-control, cross-sectional study the frequency of the MTHFR 677C --> T and the 1298A --> C polymorphism was compared between patients with hypertension-related chronic renal failure (n = 90), patients with essential hypertension without kidney injury (n = 90), and healthy individuals (n = 90) who were matched for age and gender.
|
16280279 |
2005 |
|
rs1416580204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the three described polymorphisms, only the RAGE Gly82Ser genotype frequency was significantly increased in the group with advanced nephropathy (11%) defined by a chronic renal failure compared to the three others groups: no nephropathy, 5%; incipient (microalbuminuria) 5%; established (macroalbuminuria), 2%) (P=0.04).
|
15803111 |
2005 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of the HFE mutations (0.017 for C282Y mutation and 0.124 for H63D mutation) did not differ between patients with CRI and healthy controls.
|
16138214 |
2005 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of the HFE mutations (0.017 for C282Y mutation and 0.124 for H63D mutation) did not differ between patients with CRI and healthy controls.
|
16138214 |
2005 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the three described polymorphisms, only the RAGE Gly82Ser genotype frequency was significantly increased in the group with advanced nephropathy (11%) defined by a chronic renal failure compared to the three others groups: no nephropathy, 5%; incipient (microalbuminuria) 5%; established (macroalbuminuria), 2%) (P=0.04).
|
15803111 |
2005 |
|
rs3743930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of our patients had amyloidosis but two with E148Q/E148Q had a family history of amyloidosis and one had rapidly progressive glomerulonephritis secondary to vasculitis, which progressed to chronic renal failure.
|
15458961 |
2005 |
|
rs515299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, a heterozygous mutation (causing an S890I change) in factor H of complement was found in the patient who developed chronic renal failure but not in her sister, who presented with exclusive neurologic symptoms.
|
15800115 |
2005 |
|
rs61752717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, 43 patients had a family history of chronic renal failure, and 15 (35%) were homozygous for M694V.
|
15942916 |
2005 |
|
rs699
|
|
|
0.040 |
GeneticVariation |
BEFREE |
SNPs Met235Thr in angiotensinogen, T>C (-344) in aldosterone synthase, and G>A (-1903) in chymase genes are significantly associated with diabetic chronic renal insufficiency in Indian patients and warrant replication in larger sample sets.
|
16672053 |
2006 |
|
rs1267969615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNPs Met235Thr in angiotensinogen, T>C (-344) in aldosterone synthase, and G>A (-1903) in chymase genes are significantly associated with diabetic chronic renal insufficiency in Indian patients and warrant replication in larger sample sets.
|
16672053 |
2006 |
|
rs7903146
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The diabetes-conferring risk alleles at rs7903146 and rs7901695 were significantly associated with CKD progression among ARIC participants overall and among those without baseline diabetes.
|
18650481 |
2008 |
|
rs3779748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another SNP, rs3779748 in EYA1, was significantly associated with CKD at ARIC visit 1 (odds ratio per each T allele 1.22, p = 0.01), but only with eGFR and cystatin C in FHS.
|
18522750 |
2008 |
|
rs6495446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The intronic SNP rs6495446 in the gene MTHFS was significantly associated with CKD among white ARIC participants at visit 4: the odds ratio per each C allele was 1.24 (95% CI 1.09-1.41, p = 0.001).
|
18522750 |
2008 |
|
rs7901695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The diabetes-conferring risk alleles at rs7903146 and rs7901695 were significantly associated with CKD progression among ARIC participants overall and among those without baseline diabetes.
|
18650481 |
2008 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.
|
19272686 |
2009 |
|
rs1799983
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.
|
18413200 |
2009 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.
|
19272686 |
2009 |