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rs10906850
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GWAS identified a novel genome-wide associated locus for mild to moderate CKD nearby <i>NMT2</i> (rs10906850, <i>p</i> = 3.7 × 10<sup>-8</sup>) that replicated in the United Kingdom Biobank white British (<i>p</i> = 0.008).
|
31178898 |
2019 |
|
rs1126616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the rs1126616 single nucleotide polymorphism (SNP) of the <i>SPP1</i> gene is independently associated with a higher incidence of CVE in a cohort of CKD patients and that it could be used to predict CVE risk.
|
31036794 |
2019 |
|
rs11575542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The highly heritable DA excretion trait is substantially influenced by a previously uncharacterized common coding variant (Arg462Gln) at the DDC gene that affects multiple renal tubular and glomerular traits, and predicts accelerated functional decline in chronic kidney disease.
|
30911067 |
2019 |
|
rs1564858
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race.
|
30863424 |
2019 |
|
rs495392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of the allele T of the SNP rs495392 of the Klotho gene is associated with a decrease in the odds of progression of atheromatosis in CKD patients.
|
30010839 |
2019 |
|
rs5854292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share risk factors, and recent meta-analysis confirmed that NAFLD is an independent risk factor for incident CKD.<sup>1</sup> Genetic variants associated with NAFLD, such as patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409<sup>2</sup> and transmembrane 6 superfamily member 2 (TM6SF2) rs5854292,<sup>2</sup> have been reported to be associated with renal function in NAFLD subjects.
|
31546054 |
2019 |
|
rs7041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher 25(OH)D was not associated with incident CKD overall, but it was associated with lower odds of incident CKD among participants with the GG or GT genotype at rs7041 in the gene encoding DBP [OR, 0.69 per 5 ng/mL higher 25(OH)D; 95% CI, 0.51 to 0.93; P-interaction = 0.005].
|
30668751 |
2019 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals.
|
30763699 |
2019 |
|
rs2333227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small.
|
30278820 |
2018 |
|
rs270184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD.
|
29779033 |
2018 |
|
rs373863828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Linear and logistic regression models were used to analyse the association of the A allele of CREBRF rs373863828 with BMI, log-transformed BMI, waist circumference, type 2 diabetes, gout and CKD in 2286 adults.
|
29721634 |
2018 |
|
rs3770636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD.
|
29779033 |
2018 |
|
rs7069102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7069102 polymorphism in the Sirt1 gene is associated with LV concentric remodeling in two independent cohorts of stages G5D and G1-5 CKD patients.
|
29702498 |
2018 |
|
rs74183647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD.
|
29779033 |
2018 |
|
rs752977102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a novel APRT mutation (chr16:88877985 G / C; c.195 C>/G; p.His54Asp) presenting with CKD without nephrolithiasis.
|
30106368 |
2018 |
|
rs780093
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MEDLINE and EMBASE databases were searched for studies reporting on the association between GCKR variants (rs1260326, rs780094, and rs780093) and coronary artery disease (CAD), estimated glomerular filtration rate (eGFR), and chronic kidney disease (CKD).
|
30352097 |
2018 |
|
rs780094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MEDLINE and EMBASE databases were searched for studies reporting on the association between GCKR variants (rs1260326, rs780094, and rs780093) and coronary artery disease (CAD), estimated glomerular filtration rate (eGFR), and chronic kidney disease (CKD).
|
30352097 |
2018 |
|
rs78351985
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD.
|
29779033 |
2018 |
|
rs11864909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The obtained results suggest an association of rs11864909 with chronic kidney disease secondary to chronic tubulointerstinal nephritis.
|
28954491 |
2017 |
|
rs188780113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among polymorphisms identified in the present study, rs76974938 [C/T (D67N)] of C21orf59 and rs188780113 [G/A (R478C)] of ATG2A may be novel determinants of estimated glomerular filtration rate and chronic kidney disease or of the serum concentration of uric acid, respectively.
|
28410202 |
2017 |
|
rs2467853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for clinical factors, kidney function was associated with BRAP rs3782886 and SPATA5L1 rs2467853 and the GRS for CKD that we developed was associated CKD.
|
29016630 |
2017 |
|
rs334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using regression analyses, we tested rs334 for association with eGFR and CKD, adjusting for age and sex. eGFR was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation and CKD was defined as eGFR < 60 mL/min/1.73 m<sup>2</sup>.
|
28115816 |
2017 |
|
rs3782886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for clinical factors, kidney function was associated with BRAP rs3782886 and SPATA5L1 rs2467853 and the GRS for CKD that we developed was associated CKD.
|
29016630 |
2017 |
|
rs3816527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pentraxin 3 AA genotype SNP rs3816527 can be considered as a potential biomarker and a risk factor for CKD patients, especially hypertensive patients, and specifically as an independent predictor of hypertension in CKD.
|
27838804 |
2017 |
|
rs41507953
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD.
|
28552948 |
2017 |