|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population.
|
11507049 |
2001 |
|
rs5030739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population.
|
11507049 |
2001 |
|
rs627928
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To further test for potential associations between genes and increased risk for disease, the three missense polymorphisms (Ile97Leu, Arg462Gln, and Glu541Asp) were genotyped in 438 patients with familial PC and in 510 population-based control subjects.
|
12022038 |
2002 |
|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although no difference in allele frequency at Ser217Leu between patients with PCa and controls has been reported in a Western population, this polymorphism is a potential indicator of PCa risk in Japanese men and it should be examined in other ethnic groups.
|
12949798 |
2003 |
|
rs137852593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AR R726L allele does not account for a significant proportion of early-onset and/or familial prostate cancer in the United States.
|
12539229 |
2003 |
|
rs78105154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An epidemiological study was done in sporadic PCa (n=98) and BPH (n=143) using 1 novel (Ser627Leu) and 2 previously described polymorphisms of the HPC2/ELAC2 gene.
|
12949798 |
2003 |
|
rs486907
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported.
|
15534086 |
2004 |
|
rs74315364
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported.
|
15534086 |
2004 |
|
rs17879961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
I157T was identified in 16% of men with familial prostate cancer (OR = 3.8; P = 0.00002).
|
15087378 |
2004 |
|
rs486907
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested.
|
15981205 |
2005 |
|
rs74315364
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested.
|
15981205 |
2005 |
|
rs1114167843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M.
|
16963262 |
2006 |
|
rs1799977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carrier frequencies of the I219V mutation were compared between hereditary prostate cancer (HPC) patients, unselected PRCA cases, patients with benign prostate hyperplasia and controls, but no differences between the sample groups were found.
|
16963262 |
2006 |
|
rs35831931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M.
|
16963262 |
2006 |
|
rs536562413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carrier frequencies of the I219V mutation were compared between hereditary prostate cancer (HPC) patients, unselected PRCA cases, patients with benign prostate hyperplasia and controls, but no differences between the sample groups were found.
|
16963262 |
2006 |
|
rs63750109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M.
|
16963262 |
2006 |
|
rs486907
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the virus was rarely (1/66) detected in familial prostate cancer patients heterozygous for R462Q or carrying the wild type allele.
|
18823818 |
2008 |
|
rs3803185
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs627928
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls.
|
18767027 |
2008 |
|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was conducted to confirm the association of a G638A polymorphism, Arg213His, in SULT1A1 with familial prostate cancer risk in a Japanese population.
|
18368507 |
2008 |
|
rs117251022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs1374051619
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls.
|
18767027 |
2008 |
|
rs34301344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs755100942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs9282861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was conducted to confirm the association of a G638A polymorphism, Arg213His, in SULT1A1 with familial prostate cancer risk in a Japanese population.
|
18368507 |
2008 |