|
rs4242382
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis.
|
24586834 |
2014 |
|
rs137852593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AR R726L allele does not account for a significant proportion of early-onset and/or familial prostate cancer in the United States.
|
12539229 |
2003 |
|
rs3803185
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study provides strong confirmation of the important role of ARLTS1 Cys148Arg variant as a contributor in PCa predisposition and a potential marker for aggressive disease outcome.
|
22028916 |
2011 |
|
rs3803185
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs117251022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs34301344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs755100942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data.
|
18337727 |
2008 |
|
rs1447295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of SNP rs1447295 and microsatellite marker DG8S737 with familial prostate cancer and high grade disease.
|
20639049 |
2010 |
|
rs17879961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
I157T was identified in 16% of men with familial prostate cancer (OR = 3.8; P = 0.00002).
|
15087378 |
2004 |
|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the stratified analyses for Ser217Leu polymorphism, there was significantly increased prostate cancer risk in Asian and Caucasian populations, and studies using sporadic and familial prostate cancer cases.
|
20231859 |
2010 |
|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although no difference in allele frequency at Ser217Leu between patients with PCa and controls has been reported in a Western population, this polymorphism is a potential indicator of PCa risk in Japanese men and it should be examined in other ethnic groups.
|
12949798 |
2003 |
|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population.
|
11507049 |
2001 |
|
rs1374051619
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls.
|
18767027 |
2008 |
|
rs5030739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population.
|
11507049 |
2001 |
|
rs78105154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An epidemiological study was done in sporadic PCa (n=98) and BPH (n=143) using 1 novel (Ser627Leu) and 2 previously described polymorphisms of the HPC2/ELAC2 gene.
|
12949798 |
2003 |
|
rs2645429
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs2645429 was significantly associated with prostate cancer risk in a Japanese familial prostate cancer population.
|
22546838 |
2012 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Men with the HOXB13 G84E variant had a 4.51-fold higher relative risk of PCa compared with non-carriers (95 % CI 3.28-6.20).
|
24026887 |
2014 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A rare but recurrent missense mutation (G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer.
|
22841674 |
2014 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer.
|
24722062 |
2014 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We evaluated the G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer.
|
22714738 |
2012 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A rare recurrent missense variant in HOXB13 (rs138213197/G84E) was recently reported to be associated with hereditary prostate cancer.
|
25595936 |
2015 |
|
rs10486567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis.
|
24586834 |
2014 |
|
rs1799977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carrier frequencies of the I219V mutation were compared between hereditary prostate cancer (HPC) patients, unselected PRCA cases, patients with benign prostate hyperplasia and controls, but no differences between the sample groups were found.
|
16963262 |
2006 |
|
rs35831931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Second, the samples from Finnish hereditary prostate cancer (HPC) families were used for the screening of MLH1 mutations which produced twelve MLH1 sequence variants including two missense mutations, I219V, as in the PRCA-colon cancer patient, and V647M.
|
16963262 |
2006 |