|
rs16896923
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC.
|
28881764 |
2017 |
|
rs189897
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Among them, SNP rs189897 showed the strongest association with a P-value of 6.85 x 10(-8) (OR=3.18, 95% CI=1.94-5.21), suggesting that a genetic variation(s) in ITGA9 may influence susceptibility to NPC in the Malaysian Chinese population.
|
19478819 |
2009 |
|
rs2076483
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC.
|
28881764 |
2017 |
|
rs2212020
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The combined analysis of the two sets of samples found an SNP in intron 3 of the ITGA9 (integrin-alpha 9) gene, rs2212020, to be strongly associated with NPC (P=8.27 x 10(-7), odds ratio (OR)=2.24, 95% confidence intervals (CI)=1.59-3.15).
|
19478819 |
2009 |
|
rs2517713
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The rs2517713 SNP located downstream of HLA-A was significantly associated with NPC (P = 1.08 × 10(-91), odds ratio [OR] = 0.58, 95 % confidence interval [CI] = 0.55-0.61).
|
26307051 |
2015 |
|
rs28421666
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In this study, in southern China, where NPC is endemic, a single nucleotide polymorphism (SNP) in the EBV-encoded <i>RPMS1</i> gene (locus 155391: G > A [G155391A]) and seven host SNPs (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with NPC risk in 50 NPC cases versus 54 hospital-based controls with throat washing specimens and 1925 NPC cases versus 1947 hospital-based controls with buffy coat samples, respectively.
|
29221111 |
2017 |
|
rs4977756
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our results also provide support for associations reported from published NPC GWAS-rs6774494 (P = 1.5 × 10(-12); located in the MECOM gene region), rs9510787 (P = 5.0 × 10(-10); located in the TNFRSF19 gene region), and rs1412829/rs4977756/rs1063192 (P = 2.8 × 10(-8), P = 7.0 × 10(-7), and P = 8.4 × 10(-7), respectively; located in the CDKN2A/B gene region).
|
26545403 |
2016 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We confirmed that Arg399Gln polymorphism of XRCC1 gene is a potential predictor for susceptibility to NPC, especially for Asians.
|
30095663 |
2018 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1 gene, the RsaI polymorphism of CYP2E1 gene, the -1306C>T polymorphism of MMP-2 gene and the Arg72Pro polymorphism of p53 gene might be related to increased risks of nasopharyngeal carcinoma under different genetic comparison models, while the Arg194Trp and Arg280His polymorphisms of XRCC1 gene and the 309T>G polymorphism of MDM2 gene might not contribute to the risk of nasopharyngeal carcinoma.
|
25481674 |
2015 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Here, we investigated interactions of XRCC1 Arg399Gln and XRCC2 Arg188His polymorphisms and environmental factors in modulating susceptibility to NPC in Northeast India.
|
27356695 |
2016 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our study provides an estimate of allele and genotype frequencies of XRCC1Arg280His, XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms in the Malaysian population and showed no association with nasopharyngeal cancer.
|
24761895 |
2014 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Compared with those with the Arg399Arg genotype, the risk for NPC was not significantly different in individuals with the Arg399Gln genotype (OR = 0.82; 95% CI, 0.62-1.08) and the Gln399Gln genotype (OR = 1.20; 95% CI, 0.69-2.06).
|
16796765 |
2006 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
ERCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma.
|
25025378 |
2014 |
|
rs13181
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients.
|
29912899 |
2018 |
|
rs13181
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Lys/Lys genotype of XPD Lys751Gln polymorphism was associated with increased NPC risk (OR = 1.60, 95% CI = 1.06-2.43).
|
29121049 |
2017 |
|
rs13181
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our study provides an estimate of allele and genotype frequencies of XRCC1Arg280His, XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms in the Malaysian population and showed no association with nasopharyngeal cancer.
|
24761895 |
2014 |
|
rs13181
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, XPD Lys751Gln polymorphism was significantly associated with susceptibility to LC and NPC and the Lys allele and Lys/Lys genotype of XPD Lys751Gln polymorphism may be a risk factor for LC and NPC.
|
24443924 |
2014 |
|
rs13181
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A significant association was observed between XPD K75</span>1Q polymorphism and the risk of NPC</span> using conditional logistic regression.
|
26086338 |
2015 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
After adjustment for sex and age, we found a reduced risk of developing NPC in individuals with the Trp194Trp genotype (OR = 0.48; 95% CI, 0.27-0.86) and the Arg194Trp genotype (OR = 0.79; 95% CI, 0.60-1.05) compared with those with the Arg194Arg genotype.
|
16796765 |
2006 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1 gene, the RsaI polymorphism of CYP2E1 gene, the -1306C>T polymorphism of MMP-2 gene and the Arg72Pro polymorphism of p53 gene might be related to increased risks of nasopharyngeal carcinoma under different genetic comparison models, while the Arg194Trp and Arg280His polymorphisms of XRCC1 gene and the 309T>G polymorphism of MDM2 gene might not contribute to the risk of nasopharyngeal carcinoma.
|
25481674 |
2015 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No associations were found between Arg194Trp and Arg280His polymorphisms with NPC risk, whereas the Arg399Gln genotype was associated with increased risk.
|
22296379 |
2011 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Meta-analyses showed that there was no statistically significant association observed between Arg194Trp/Arg280His variants in the XRCC1 gene and NPC risk with all genetic models, when relatively larger samples were pooled into the update meta-analysis.
|
30095663 |
2018 |
|
rs1799782
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results showed that XRCC1 codon 194 Trp allele was associated with an increased risk of NPC (odds ratio [OR] = 1.828, 95% confidence interval [CI]: 1.286-2.598), and XPD codon 751Gln allele was associated with a borderline decrease of NPC (OR = 0.600, 95% CI: 0.361-1.000); combination analysis showed that individuals with both putative genotypes of XPD codon 751 Lys/Lys and XRCC1 codon 194 Arg/Trp or Trp/Trp have a significantly elevated risk of NPC (OR = 2.708, 95% CI: 1.338-5.478).
|
17630853 |
2007 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1 gene, the RsaI polymorphism of CYP2E1 gene, the -1306C>T polymorphism of MMP-2 gene and the Arg72Pro polymorphism of p53 gene might be related to increased risks of nasopharyngeal carcinoma under different genetic comparison models, while the Arg194Trp and Arg280His polymorphisms of XRCC1 gene and the 309T>G polymorphism of MDM2 gene might not contribute to the risk of nasopharyngeal carcinoma.
|
25481674 |
2015 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings suggest that miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may singly or collaboratively contribute to the risk of NPC.
|
23504554 |
2013 |