|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC.
|
28881764 |
2017 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, there was a significantly increased risk of NPC associated with the combined risk genotypes (i.e., p53 rs1042522 Arg/Pro + Pro/Pro, MDM2 rs2279244 G/T + G/G, PTEN rs11202592 C/C, AKT1 rs1130233 A/A).
|
24632578 |
2014 |
|
rs25489
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1 gene, the RsaI polymorphism of CYP2E1 gene, the -1306C>T polymorphism of MMP-2 gene and the Arg72Pro polymorphism of p53 gene might be related to increased risks of nasopharyngeal carcinoma under different genetic comparison models, while the Arg194Trp and Arg280His polymorphisms of XRCC1 gene and the 309T>G polymorphism of MDM2 gene might not contribute to the risk of nasopharyngeal carcinoma.
|
25481674 |
2015 |
|
rs25489
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No associations were found between Arg194Trp and Arg280His polymorphisms with NPC risk, whereas the Arg399Gln genotype was associated with increased risk.
|
22296379 |
2011 |
|
rs25489
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Meta-analyses showed that there was no statistically significant association observed between Arg194Trp/Arg280His variants in the XRCC1 gene and NPC risk with all genetic models, when relatively larger samples were pooled into the update meta-analysis.
|
30095663 |
2018 |
|
rs25489
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Distribution and haplotype associations of XPD Lys751Gln, XRCC1 Arg280His and XRCC1 Arg399Gln polymorphisms with nasopharyngeal carcinoma in the Malaysian population.
|
24761895 |
2014 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC.
|
28881764 |
2017 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Taken together, our results showed that the variant C in rs2910164 was associated with the predisposition of NPC in Chinese population.
|
22711332 |
2013 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma.
|
29127520 |
2018 |
|
rs2910164
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the C allele and CC genotype of rs2910164 were found to be associated with an inverse risk of nasopharyngeal carcinoma (GG vs CC:OR=0.586, 95% CI=0.405-0.847, p=0.005; CC vs CG+GG:OR=1.496, 95% CI=1.189-1.881, p=0.001).
|
26214637 |
2015 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Taken together, our findings based on large-scale sample size suggested rs861539 at XRCC3 to be associated with NPC risk through recessive model.
|
27639382 |
2016 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To investigate the effect of XPD Lys751Gln, XRCC1 Arg399Gln, Arg194Trp, Arg280His, and XRCC3 Thr241Met polymorphisms on the risk of nasopharyngeal carcinoma (NPC), a population-based case-control study of 153 NPC patients and 168 healthy controls among Sichuan population was conducted.
|
17630853 |
2007 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
As for the gene-environment interaction, we have firstly provided evidence showing that there is an obvious joint effect of XRCC3 rs861539</span> CT and TT genotypes with individual smoking habits on increased NPC risk.
|
25687493 |
2015 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In this pilot case-control study, we tested the association between TGFB1 T869C codon 10 Leu/Pro (rs1982073), XRCC1 G28152A codon 399 Arg/Gln (rs25487), and XRCC3 C18067T codon 241 Thr/Met (rs861539) single-nucleotide polymorphisms (SNPs) and late reaction to radiotherapy in 60 nasopharyngeal cancer patients.
|
20334523 |
2010 |
|
rs11556218
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The meta-analysis indicated that rs11556218 T/G was associated with a significant increased risk of cancer (G vs. T, OR=1.321, 95% CI=1.142-1.528, P <0.001; TG vs. TT, OR=1.665, 95% CI=1.448-1.915, P<0.001; GG+TG vs. TT, OR=1.622, 95% CI=1.416-1.858, P<0.001),as well as nasopharyngeal carcinoma and colorectal cancer.
|
24969906 |
2014 |
|
rs11556218
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data suggested that IL16 rs11556218 T/G polymorphism was associated with increased susceptibility to NPC through increasing the production of serum IL-16 levels.
|
24101193 |
2014 |
|
rs11556218
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs11556218 T/G polymorphism of IL-16 gene was significantly associated with the susceptibility to NPC.
|
19758567 |
2009 |
|
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 698 native Taiwanese consisting of 176 cases and 522 controls were enrolled in this hospital-based study, and three single-nucleotide polymorphism sites at promoter regions of IL10, A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and their interaction with smoking habit for NPC risk were evaluated.
|
23898109 |
2013 |
|
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G polymorphisms has a significantly association with the increased risk of esophageal cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and rs1800896 A>G under allele and dominant models could increase the risk of nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs under allele model were closely related to the susceptibility to oral cancer.
|
27002767 |
2016 |
|
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC.
|
28881764 |
2017 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings suggest that miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may singly or collaboratively contribute to the risk of NPC.
|
23504554 |
2013 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1 gene, the RsaI polymorphism of CYP2E1 gene, the -1306C>T polymorphism of MMP-2 gene and the Arg72Pro polymorphism of p53 gene might be related to increased risks of nasopharyngeal carcinoma under different genetic comparison models, while the Arg194Trp and Arg280His polymorphisms of XRCC1 gene and the 309T>G polymorphism of MDM2 gene might not contribute to the risk of nasopharyngeal carcinoma.
|
25481674 |
2015 |
|
rs13347
|
|
|
0.020 |
GeneticVariation |
BEFREE |
All these findings suggest that CD44 rs13347C>T polymorphism may affect NPC development by improving CD44 expression.
|
23883608 |
2013 |
|
rs13347
|
|
|
0.020 |
GeneticVariation |
BEFREE |
All these findings suggest that CD44 rs13347C>T and rs115214213T>C polymorphisms may affect NPC development by improving CD44 expression.
|
25268088 |
2014 |
|
rs13347
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After statistical analysis we found that the minor alleles of rs13347 C/T and rs115214213 T/C are associated with NPC (OR = 1.94 95% CI = 1.44-2.62; OR = 2.07 95% CI = 1.65-2.60).
|
25268088 |
2014 |