|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
(3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT).No publication bias was observed.
|
22374238 |
2012 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant difference in the distribution of the haplotype suggests that the PTPN22 gene rather than rs2476601 is involved in the development of AITD in the Japanese population.
|
20615141 |
2010 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D).
|
19090780 |
2009 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
|
24697361 |
2014 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs10004195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype (AGT) frequency of TLR10 rs4129009, rs11096956, and rs10004195 was higher in the AITD group than in healthy controls (OR=2.1, corrected p=0.03).
|
25295614 |
2015 |
|
rs10181656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypes of rs10181656 differed significantly in GD patients from controls (p=0.012); G allele frequencies were significantly higher in AITD patients than the controls (p=0.014 and 0.031, respectively).
|
25019342 |
2014 |
|
rs1053005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele A and AA genotype of SNP rs1053005 may protect individuals from the susceptibility to AITD and their frequency decreased in AITD patients.
|
24081513 |
2013 |
|
rs1061502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: <i>P</i> = 0.017, OR = 1.968; allele G: <i>P</i> = 0.018, OR = 1.946; rs1061502: AG genotype: <i>P</i> = 0.029, OR = 1.866; allele G: <i>P</i> = 0.031, OR = 1.847).
|
30774658 |
2019 |
|
rs1131665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: <i>P</i> = 0.017, OR = 1.968; allele G: <i>P</i> = 0.018, OR = 1.946; rs1061502: AG genotype: <i>P</i> = 0.029, OR = 1.866; allele G: <i>P</i> = 0.031, OR = 1.847).
|
30774658 |
2019 |
|
rs1179251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
|
28839453 |
2017 |
|
rs12492609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the allele T of rs12492609 in <i>TMEM39A</i> was associated with AITD and Hashimoto's thyroiditis (HT) (<i>p</i> = 0.023; <i>p</i> = 0.028 respectively).
|
31553233 |
2019 |
|
rs1267634673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Investigation of an individual with AITD who was incorrectly diagnosed with RTH led to the fortuitous discovery of a THRB gene variant (G339S) in the proposita's father, paternal aunt, and cousin.
|
23806029 |
2013 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs17445836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs17445836</span> and rs2280381 were associated with the presence of an antimicrosomal antibody (AmiA), and rs2280381 was also associated with the presence of an antithyroglobulin antibody (ATA) in AITD.
|
25989711 |
2015 |
|
rs17593222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the allele G of rs17593222 may increase the ophthalmopathy risk in AITD patients.
|
24081513 |
2013 |
|
rs17855750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.
|
30694795 |
2019 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
rs2048722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum levels of TPOAb were significantly higher in AITD patients with TPO rs2071400 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0295), and were also significantly higher in AITD patients with TPO rs2048722 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0056).
|
28845025 |
2017 |
|
rs2069550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Latitude and ethnicity significantly affected the association between rs2076740 and rs2069550 polymorphisms and AITD, indicating their protective effects in allele or dominant model (P = 0.012, 0.012, 0.012, 0.009, 0.009).
|
30139952 |
2019 |
|
rs2071400
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum levels of TPOAb were significantly higher in AITD patients with TPO rs2071400 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0295), and were also significantly higher in AITD patients with TPO rs2048722 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0056).
|
28845025 |
2017 |