|
rs237025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the association of SUMO4 M55V variant was stronger in type 1 diabetic patients complicated with AITD (OR, 1.62; 95% CI, 1.06-2.47; P = 0.023) and in patients who have neither type 1 diabetes-susceptible class II HLA, DRB1*0405 nor DRB1*0901 (OR, 2.28; 95% CI, 1.34-3.87; P = 0.0018).
|
16735488 |
2006 |
|
rs745826707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the association of SUMO4 M55V variant was stronger in type 1 diabetic patients complicated with AITD (OR, 1.62; 95% CI, 1.06-2.47; P = 0.023) and in patients who have neither type 1 diabetes-susceptible class II HLA, DRB1*0405 nor DRB1*0901 (OR, 2.28; 95% CI, 1.34-3.87; P = 0.0018).
|
16735488 |
2006 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D).
|
19090780 |
2009 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs2292399
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs2903692
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs763361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant difference in the distribution of the haplotype suggests that the PTPN22 gene rather than rs2476601 is involved in the development of AITD in the Japanese population.
|
20615141 |
2010 |
|
rs3118470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped the five SNPs (rs12760457, rs2797415, rs1310182, rs2476599, and rs3789604) of the PTPN22 and the two SNPs (rs706778 and rs3118470 in the IL2RA gene) in 456 Japanese patients with AITD (286 with GD, 170 with Hashimoto's thyroiditis) and 221 matched Japanese control subjects.
|
20615141 |
2010 |
|
rs3789604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped the five SNPs (rs12760457, rs2797415, rs1310182, rs2476599, and rs3789604) of the PTPN22 and the two SNPs (rs706778 and rs3118470 in the IL2RA gene) in 456 Japanese patients with AITD (286 with GD, 170 with Hashimoto's thyroiditis) and 221 matched Japanese control subjects.
|
20615141 |
2010 |
|
rs706778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped the five SNPs (rs12760457, rs2797415, rs1310182, rs2476599, and rs3789604) of the PTPN22 and the two SNPs (rs706778 and rs3118470 in the IL2RA gene) in 456 Japanese patients with AITD (286 with GD, 170 with Hashimoto's thyroiditis) and 221 matched Japanese control subjects.
|
20615141 |
2010 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
(3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT).No publication bias was observed.
|
22374238 |
2012 |
|
rs1053005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele A and AA genotype of SNP rs1053005 may protect individuals from the susceptibility to AITD and their frequency decreased in AITD patients.
|
24081513 |
2013 |
|
rs1267634673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Investigation of an individual with AITD who was incorrectly diagnosed with RTH led to the fortuitous discovery of a THRB gene variant (G339S) in the proposita's father, paternal aunt, and cousin.
|
23806029 |
2013 |
|
rs17593222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the allele G of rs17593222 may increase the ophthalmopathy risk in AITD patients.
|
24081513 |
2013 |
|
rs3733197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification for specific autoantibodies in AI</span>TD patients TGAb positive when compared with SE (shared epitope) positive showed a significant association in rs3733197 SNP (P=0.010, OR=0.68 and 95%=CI 0.51-0.91).
|
24127308 |
2013 |
|
rs6479778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fine mapping of the AITD locus, 10q, showed replicated association of the AITD phenotype (both GD and HT) with SNP rs6479778.
|
23118423 |
2013 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
|
24697361 |
2014 |
|
rs10181656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypes of rs10181656 differed significantly in GD patients from controls (p=0.012); G allele frequencies were significantly higher in AITD patients than the controls (p=0.014 and 0.031, respectively).
|
25019342 |
2014 |
|
rs3788013
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population.
|
25211447 |
2014 |
|
rs661561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in TNFAIP3 gene locus (rs598493, rs610604 and rs661561) were detected in a set of 667 patients with AITD and 301 controls in Han Chinese population using the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform.
|
24798189 |
2014 |
|
rs10004195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype (AGT) frequency of TLR10 rs4129009, rs11096956, and rs10004195 was higher in the AITD group than in healthy controls (OR=2.1, corrected p=0.03).
|
25295614 |
2015 |
|
rs17445836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs17445836</span> and rs2280381 were associated with the presence of an antimicrosomal antibody (AmiA), and rs2280381 was also associated with the presence of an antithyroglobulin antibody (ATA) in AITD.
|
25989711 |
2015 |