|
rs7574865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> This meta-analysis showed a significant association between <i>STAT4</i> rs7574865 polymorphism and AITD susceptibility.
|
30666271 |
2018 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
(3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT).No publication bias was observed.
|
22374238 |
2012 |
|
rs7514229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age.
|
27556446 |
2016 |
|
rs4840568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele A of rs4840568 linked to the susceptibility of the AITD teenagers.
|
30351170 |
2018 |
|
rs2900180
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele analysis found that T allele of rs4836834, G allele of rs10760130, A allele of rs10818488, T allele of rs2239658 and T allele of rs2900180 were significantly higher in GD and AITD patients.
|
26699338 |
2016 |
|
rs17445836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs17445836</span> and rs2280381 were associated with the presence of an antimicrosomal antibody (AmiA), and rs2280381 was also associated with the presence of an antithyroglobulin antibody (ATA) in AITD.
|
25989711 |
2015 |
|
rs2280381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs17445836 and rs2280381 were associated with the presence of an antimicrosomal antibody (AmiA), and rs2280381 was also associated with the presence of an antithyroglobulin antibody (ATA) in AITD.
|
25989711 |
2015 |
|
rs6479778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fine mapping of the AITD locus, 10q, showed replicated association of the AITD phenotype (both GD and HT) with SNP rs6479778.
|
23118423 |
2013 |
|
rs237025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the association of SUMO4 M55V variant was stronger in type 1 diabetic patients complicated with AITD (OR, 1.62; 95% CI, 1.06-2.47; P = 0.023) and in patients who have neither type 1 diabetes-susceptible class II HLA, DRB1*0405 nor DRB1*0901 (OR, 2.28; 95% CI, 1.34-3.87; P = 0.0018).
|
16735488 |
2006 |
|
rs745826707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the association of SUMO4 M55V variant was stronger in type 1 diabetic patients complicated with AITD (OR, 1.62; 95% CI, 1.06-2.47; P = 0.023) and in patients who have neither type 1 diabetes-susceptible class II HLA, DRB1*0405 nor DRB1*0901 (OR, 2.28; 95% CI, 1.34-3.87; P = 0.0018).
|
16735488 |
2006 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs2292399
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs2903692
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
rs2736340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
rs763361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
rs17593222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the allele G of rs17593222 may increase the ophthalmopathy risk in AITD patients.
|
24081513 |
2013 |
|
rs7629750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the frequency of allele A at rs7629750 in AITD patients with onset age ≤18 years old was higher than that in AITD patients with onset age ≥19 (<i>p</i> = 0.046).
|
31553233 |
2019 |
|
rs7975232
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the present study suggested that <i>VDR</i> rs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk.
|
29765404 |
2018 |
|
rs2276886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we first reported that the polymorphisms in IL8, RANTES and MIG genes are associated with the development of AITD, and that the MIG rs2276886 AG genotype is associated with the intractability of GD.
|
27245471 |
2016 |
|
rs1267634673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Investigation of an individual with AITD who was incorrectly diagnosed with RTH led to the fortuitous discovery of a THRB gene variant (G339S) in the proposita's father, paternal aunt, and cousin.
|
23806029 |
2013 |
|
rs2076740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Latitude and ethnicity significantly affected the association between rs2076740 and rs2069550 polymorphisms and AITD, indicating their protective effects in allele or dominant model (P = 0.012, 0.012, 0.012, 0.009, 0.009).
|
30139952 |
2019 |