Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
UNIPROT |
|
|
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
<b>Patients & methods:</b> Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV <i>in-situ</i> hybridization were analyzed.
|
31157548 |
2019 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
BEFREE |
A significantly higher prevalence for p16 methylation was seen in central vs. peripheral lung tumors.
|
15578700 |
2005 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
A subset of the lung tumors (8/28) displayed reduced levels of p16(Ink4a) expression (P = 0.02).
|
16482519 |
2006 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
CTD_human |
Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: a prospective study in high-risk patients without invasive cancer.
|
12115568 |
2002 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
LHGDN |
Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.
|
11960384 |
2002 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Alterations of the p16(ink4a) gene in resected nonsmall cell lung tumors and exfoliated cells within sputum.
|
11920642 |
2002 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Based on the concordance of biomarkers in lung tumours and corresponding sputum, and the low prevalence in cancer-free individuals, we selected seven markers for a nested case-control study: microsatellite instability of D9S942; loss of heterozygosity of D9S286, D9S942, GATA49D12, and D13S170; and methylation of p16INK4a and RARbeta.
|
17973238 |
2007 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
CTD_human |
DNA methylation markers and early recurrence in stage I lung cancer.
|
18337602 |
2008 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
RGD |
Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine.
|
19409458 |
2009 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
Effects of exogenous p16(ink4a) gene on biological behaviors of human lung cancer cells.
|
17393105 |
2007 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Expression of p53, pRB, and p16 in lung tumours: a validation study on tissue microarrays.
|
12898597 |
2003 |
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
LHGDN |
Extending the p16-Leiden tumour spectrum by respiratory tract tumours.
|
14985402 |
2004 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
H1299 lung cancer cells, lacking Fhit, Wwox, p16(INK4a) and Rassf1a expression due to epigenetic modifications, were used to assess efficacy of epigenetically targeted protocols in suppressing growth of lung tumors, by injection of 5-aza-2-deoxycytidine (AZA) and trichostatin A (TSA) in nude mice with established H1299 tumors.
|
17019711 |
2007 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers.
|
16533425 |
2006 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers.
|
16533425 |
2006 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication.
|
15254707 |
2004 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
CTD_human |
Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat.
|
20135361 |
2010 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
BEFREE |
In multivariate analysis, p16 hypermethylation was more prevalent in lung tumours from male than female patients (P = 0.018) and in squamous cell carcinomas than in adenocarcinomas (P = 0.025).
|
22217548 |
2012 |
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
In order to explore the possibility of a selective deregulation of p15(INK4b) in human lung carcinogenesis, we studied p15(INK4b) status in neuroendocrine (NE) lung tumours where homozygous deletions of the p16(INK4a)/p14(ARF) locus are rarely observed.
|
11641784 |
2001 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Methylation of p16 was observed in 34% (22/64) of the lung tumours examined.
|
12918069 |
2003 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
BEFREE |
Methylation of p16 was observed in 34% (22/64) of the lung tumours examined.
|
12918069 |
2003 |
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
Methylation of the p16 and ER genes was very common (80 and 50%, respectively) in beryllium-induced lung tumors; both genes were methylated in 40% of the tumors.
|
11872642 |
2002 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
CTD_human |
Methylation of the p16 and ER genes was very common (80 and 50%, respectively) in beryllium-induced lung tumors; both genes were methylated in 40% of the tumors.
|
11872642 |
2002 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
RGD |
Methylation of the p16 and ER genes was very common (80 and 50%, respectively) in beryllium-induced lung tumors; both genes were methylated in 40% of the tumors.
|
11872642 |
2002 |