|
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Moreover, 36.7% (22/60) of the non-small cell lung tumours without p16 expression showed p16 promoter methylation, detecting a significant correlation between p16 methylation and the histological subtype of squamous cell carcinomas (SCC) (P=0.04).
|
14719111 |
2004 |
|
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Moreover, and consistent with p14ARF being a determinant of CHK2 phosphorylation in lung carcinogenesis, a strong correlation between p14ARF and phospho-CHK2 (Thr68) protein expression is observed in human lung tumors (P < 0.00006).
|
16705183 |
2006 |
|
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Moreover, the reverse correlation between p16INK4a immunostaining and p16INK4a promoter hypermethylation was also only observed in nonsmoking female lung tumors.
|
15455389 |
2005 |
|
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
BEFREE |
Moreover, the reverse correlation between p16INK4a immunostaining and p16INK4a promoter hypermethylation was also only observed in nonsmoking female lung tumors.
|
15455389 |
2005 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
|
17936562 |
2007 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis.
|
12169206 |
2003 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Our analyses revealed a high frequency of aberrant hypermethylation of MTHFR, RASSF1A, and CDKN2A in lung tumors as compared with control blood samples, whereas no significant increase in methylation levels of GSTP1 and CDH1 was observed, consistent with the notion that aberrant DNA methylation occurs in a tumor-specific and gene-specific manner.
|
19118009 |
2009 |
|
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients.
|
16222700 |
2006 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
LHGDN |
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.
|
17575133 |
2007 |
|
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer.
|
18949413 |
2008 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer.
|
18243403 |
2008 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Secondly, genetic resistance to lung tumor formation appears to segregate with one particular haplotype, which also is deleted preferentially in lung adenocarcinomas of Cdkn2a heterozygous mice.
|
10365910 |
1999 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
The p14ARF transcript, which is an alternative spliced form of this locus, is also altered or deleted in a proportion of human lung cancers and has been shown to inhibit cell cycle progression as an endogenous cellular regulator of the p53 protein, raising the possibility that it might constitute an additional lung tumor suppressor gene at the 9p21 locus.
|
11414196 |
2001 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations.
|
26674347 |
2015 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
The formation of lung tumors by these chemicals involved mutations in the K-ras cancer gene and loss of heterozygosity in the region of K-ras on distal chromosome 6, while alterations in p53 and p16 were implicated in brain tumorigenesis.
|
16860786 |
2007 |
|
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.
|
16828922 |
2006 |
|
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
BEFREE |
These results substantiate the primary tumor as the origin for dysfunction of the p16 gene and implicate CpG island methylation as the major mechanism for inactivating this gene in the rat lung tumors examined.
|
9032263 |
1997 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
To conclude, systemic p16 peptide administration decreased lung tumor development in a mouse metastatic BT model without severe adverse events, as assessed by blood analyses and histological evaluation.
|
30655885 |
2019 |
|
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
To further explore the molecular mechanisms between altered TSGs promoter methylation and overexpression of DNMTs protein, we performed a tissue chromatin-immunoprecipitation polymerase chain reaction assay for lung tumors and showed that the methylated FHIT, p16(INK4a) and RARbeta promoters were bound by both DNMT protein and methyl-CpG-binding protein 2.
|
17140695 |
2007 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
We examined the tumor and the matched BAL DNA for aberrant methylation of eight gene promoters (CDH1, APC, MGMT, RASSF1A, GSTP1, p16, RAR-beta 2, and ARF) from 31 patients with primary lung tumors by quantitative fluorogenic real-time PCR.
|
15073103 |
2004 |
|
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
We have examined the expression of the human p19ARF (hp19ARF) protein in a large series of lung cancers using immunohistochemistry and showed that the protein was more frequently lost in high-grade neuroendocrine (NE) lung tumors (large cell NE carcinoma and small cell lung carcinoma; 51 of 78, 65%) than it was in non-small cell lung cancer (25 of 101, 25%).
|
9731504 |
1998 |
|
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically significantly lower expression level of the p16 protein as compared with that in normal lung stromal cells.
|
20407446 |
2010 |