|
Chronic Lymphocytic Leukemia
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL).
|
23593011 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All the deletions included the noncoding RNA locus DLEU1 (previously BCMS), which is considered to be the most likely CLL-associated candidate tumor suppressor gene within the 13q14 region.
|
19963108 |
2009 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia.
|
12094250 |
2002 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The nondeleted allele of the CAR and EST70/Leu1 genes was expressed in B-CLL specimens, including those with monoallelic loss, whereas no expression of 1B4/Leu2 was detectable in B-CLL, regardless of the 13q14 status.
|
11264177 |
2001 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Since their putative involvement in B-CLL was controversial, our present study provide support for reconsidering the DLEU1 and DLEU2 genes as B-CLL candidate genes, with a new definition of their organisation and context.
|
11691637 |
2001 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The first exons of two genes, Leu1 and Leu2, mapped in a minimally deleted 13q14.3 region, are systematically lost in B-CLL sharing a 13q14.3 deletion.
|
10516767 |
1999 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
We conclude that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
|
9395242 |
1997 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The leukemic cells from 95% of patients with B cell chronic lymphocytic leukemia (CLL) coexpress B cell differentiation antigens and the pan-T lymphocyte surface antigen CD5 (Leu 1).
|
1689356 |
1990 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Recently, we found that the G6 CRI also is expressed frequently by neoplastic CD5 (Leu1) B cells from patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma.
|
2503826 |
1989 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The monoclonal antibodies against CD8 (T suppressor/cytotoxic) antigen (Leu2/OKT8) were found to bind to leukaemic lymphocytes from a patient with chronic lymphocytic leukaemia.
|
3319675 |
1987 |
|
Chronic Lymphocytic Leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Flow cytometric analysis of forward- and right-angle light scatters demonstrated the presence of two populations of cells, one lymphoid, bearing predominantly lambda light chain surface immunoglobulin and showing phenotypic characteristics of B cell chronic lymphocytic leukemia (HLA-DR-positive, BL-1-positive, BL-2-positive, BL-7-positive, Leu-1-positive, Leu-10-positive, BL-5-negative, BL-6-negative, and OKM1-negative), and another granulocytic population expressing phenotypic features compatible with myeloid lineage (HLA-DR-negative, Leu-1-negative, BL-1-negative, BL-2-negative, BL-7-negative, Leu-10-negative, BL-5-positive, BL-6-negative, OKM1-positive, and surface immunoglobulin-negative).
|
3456199 |
1986 |
|
Small Lymphocytic Lymphoma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
Small Lymphocytic Lymphoma
|
0.110 |
Biomarker
|
disease |
BEFREE |
Recently, we found that the G6 CRI also is expressed frequently by neoplastic CD5 (Leu1) B cells from patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma.
|
2503826 |
1989 |
|
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Blood urea nitrogen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity.
|
31264924 |
2019 |
|
Eczema
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Hypothyroidism
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |