|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
The replication analysis indicates that TNFAIP3, ETS1 and TNIP1 are probably common susceptibility genes for SLE in Chinese populations, and they may contribute to the pathogenesis of multiple SLE subphenotypes.
|
22087647 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found for the single nucleotide polymorphism rs10036748 of TNIP1 with photosensitivity (odds ratio (OR) = 0.87, p = 0.01) and vasculitis (OR = 1.18, p = 0.04); rs10847697 of SLC15A4 with discoid rash (OR = 1.18, p = 0.02); rs6590330 of ETS1 with SLE of age at diagnosis <20 years (OR = 1.24, p = 8.91 x 10(-5)); rs13385731 of RasGRP3 with malar rash (OR = 1.20, p = 0.01), discoid rash (OR = 0.78, p = 0.02) and ANA (OR = 0.72, p = 0.004); rs4917014 of IKZF1 with renal nephritis (OR = 1.13, p = 0.02) and malar rash (OR = 0.83, p = 0.00038), respectively.
|
20516000 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A case-control association study was conducted on the TNIP1 single nucleotide polymorphism (SNP) rs7708392 in 364 Japanese SLE patients, 553 RA patients and 513 healthy controls.
|
20849588 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
CTD_human |
This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19).
|
19838195 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19).
|
19838195 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19).
|
19838195 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19).
|
19838195 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patients with psoriasis with TT genotype of rs10036748 in TNIP1, with lower BMI, without arthritis will achieve a better response to MTX.
|
31020648 |
2019 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific consequences subsequent to their defective function are being recognized and related to human disease states such as lupus, scleroderma, and psoriasis.
|
30402506 |
2018 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association between tumor necrosis factor-alpha induced protein 3 interacting protein 1 (TNIP1) gene and psoriasis was confirmed in people with multiple ethnicities.
|
27364786 |
2016 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Based on previous studies suggesting a role for TNIP1 in modulating cancer cell growth, we investigated its role in keratinocyte proliferation, which is clearly abnormal in psoriasis.
|
26046540 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.
|
25854761 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
|
25574825 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, our results suggest that TNFAIP3 (rs610604) and TNIP1 (rs17728338) polymorphisms confer increased risk of psoriasis and may play a vital role in its pathogenesis in our ethnic South Indian Tamils.
|
26738398 |
2015 |
|
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Strong additive effects when combining HLA-C*06 with IL23A, IL23R, IL12B, NFKB1 or TNIP1 were restricted to the severe cohort, indicating that activation of these pathways may influence disease severity in psoriasis.
|
25789703 |
2015 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, we show that the MHC and TNIP1 regions are significantly different in patients with psoriasis onset before the age of 40 (type I) compared to after 40 years of age (type II).
|
25481369 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After our first psoriasis genome-wide association study, we designed a custom genotyping array to fine-map eight genome-wide significant susceptibility loci known at that time (IL23R, IL13, IL12B, TNIP1, MHC, TNFAIP3, IL23A and RNF114) enabling genotyping of 2269 single-nucleotide polymorphisms (SNPs) in the eight loci for 2699 psoriasis cases and 2107 unaffected controls of European ancestry.
|
25182136 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We further identified previously unreported pleiotropic alleles with opposing effects on atopic dermatitis and psoriasis risk in PRKRA and ANXA6/TNIP1.
|
25574825 |
2015 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, the data suggested that HCP5, TNIP1 and TNFAIP3 may play a role in common pathogenic of psoriasis in Chinese and confer risk factors for psoriasis in various ethnic populations.
|
25264125 |
2014 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study provides empirical evidence for the gene-environment interactions between TNIP1/ANXA6 and alcohol use, CSMD1 and cigarette smoking, highlighting the importance of gene-environment interactions in the pathogenesis of psoriasis.
|
23541940 |
2013 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |