|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined.
|
22542476 |
2012 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
These include TNFAIP3 and TNIP1, which has been implicated in association studies for RA, systemic lupus erythematosus, and psoriasis.
|
21362769 |
2011 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Psoriasis and psoriatic arthritis fall into this disease spectrum, with the largest region of susceptibility coming from the MHC (most likely HLA-C, ie, C*06:02 although additional influences are also being implicated), and most of the other genetic susceptibility coming from genes involved in cytokine production, specifically genes in the Th17 pathway (IL-12B, IL-23A and IL-23R, the latter, like in AS, not seen in Asians), genes in the nuclear factor κB pathway (TNFAIP3 and TNIP1) and genes in the Th2 pathway (IL-4 and IL-13).
|
21339218 |
2011 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies.
|
20953187 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
|
20953187 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the results of multiple well-powered genome-wide association studies have identified several additional loci outside the major histocompatibility complex region associated with psoriasis risk, including three genes involved in interleukin (IL)-23 signaling (IL-23R, IL-23A, IL-12B), two genes that regulate nuclear factor-kappaB signaling (TNIP1, TNFAIP3), and two genes involved in the modulation of T-helper type 2 immune responses (IL-4, IL-13).
|
20480402 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
More recently, analysis of psoriasis genome-wide association studies in a PsA subgroup has also implicated IL23A, TNFAIP3, and TNIP1 genetic variants as conferring risk to PsA.
|
20875338 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently the results of multiple, well powered, genetic case-control studies have begun to appear providing convincing statistical evidence for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis.
|
19446472 |
2009 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.
|
31672989 |
2019 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
|
Systemic Scleroderma
|
0.440 |
Biomarker
|
disease |
BEFREE |
Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific consequences subsequent to their defective function are being recognized and related to human disease states such as lupus, scleroderma, and psoriasis.
|
30402506 |
2018 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
These data confirmed the influence of TNIP1 on an increased susceptibility to SSc and reinforced this locus as a common autoimmunity risk factor.
|
22896740 |
2013 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
The T allele of rs10036748 in the TNIP1 gene is the minor protective allele for asthma but the minor or major risk allele for systemic lupus erythematosus and systemic sclerosis in non-Hispanic white or Chinese subjects, respectively.
|
22694930 |
2012 |
|
Systemic Scleroderma
|
0.440 |
Biomarker
|
disease |
CTD_human |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
|
Systemic Scleroderma
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis.
|
21750679 |
2011 |
|
Sjogren's Syndrome
|
0.410 |
Biomarker
|
disease |
BEFREE |
Although no association has been found with the NF-kB gene itself, associations in TNFAIP3 and TNIP1 (both genome-wide significant), VCAM1 and IRAK1BP (both suggestive), point to genetic explanations for dysregulation of the NF-kB pathway in SS.
|
27431346 |
2016 |
|
Asthma
|
0.410 |
Biomarker
|
disease |
CTD_human |
A20-deficient mast cells exacerbate inflammatory responses in vivo.
|
24453940 |
2014 |