|
Sjogren's Syndrome
|
0.410 |
Biomarker
|
disease |
CTD_human |
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
|
24097067 |
2013 |
|
Sjogren's Syndrome
|
0.410 |
GeneticVariation
|
disease |
GWASCAT |
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
|
24097067 |
2013 |
|
Asthma
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
The T allele of rs10036748 in the TNIP1 gene is the minor protective allele for asthma but the minor or major risk allele for systemic lupus erythematosus and systemic sclerosis in non-Hispanic white or Chinese subjects, respectively.
|
22694930 |
2012 |
|
Asthma
|
0.410 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
|
22694930 |
2012 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive.
|
30774867 |
2019 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive.
|
30774867 |
2019 |
|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
|
27621439 |
2016 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
|
27621439 |
2016 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
|
23959881 |
2013 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
|
23959881 |
2013 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Sicca Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
|
24097067 |
2013 |
|
Pustulosis of Palms and Soles
|
0.300 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Pustulosis of Palms and Soles
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Libman-Sacks Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
|
Libman-Sacks Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Autoimmune Diseases
|
0.160 |
AlteredExpression
|
group |
BEFREE |
Genetic variants in the region of TNFAIP3 interacting protein 1 (TNIP1) are associated with autoimmune disease and reduced TNIP1 gene expression.
|
31804013 |
2019 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
In this review, we emphasize receptor signaling complexes and regulation of cytoplasmic signaling steps downstream of TLR given their association with some of the same autoimmune diseases where TNIP1 has been implicated.
|
30402506 |
2018 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
Conversely, stimulation of the pathway may also ameliorate autoimmune diseases in which TNIP1 is a susceptibility gene.
|
27129285 |
2016 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-κB and of IKBKE (IKKε), which is an NF-κB activator.
|
23944604 |
2013 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
BEFREE |
These data confirmed the influence of TNIP1 on an increased susceptibility to SSc and reinforced this locus as a common autoimmunity risk factor.
|
22896740 |
2013 |