|
Acute biphenotypic leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2.
|
9731070 |
1998 |
|
Acute biphenotypic leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia.
|
17697320 |
2007 |
|
Acute leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The MOZ-TIF2 fusion is one of a new family of chromosomal rearrangements that associate HAT activity, transcriptional coactivation, and acute leukemia.
|
9731070 |
1998 |
|
Acute leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The ETV6-NCOA2 fusion may define a novel subgroup of acute leukemia with T-lymphoid and myeloid features, which is associated with a high prevalence of NOTCH1 mutations.
|
18281529 |
2008 |
|
Acute leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions and MOZ-TIF2, revealing a tractable aberrant epigenetic circuitry mediated by KDM4C and PRMT1 in acute leukemia.
|
26766589 |
2016 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13).
|
10459350 |
1999 |
|
Acute myelomonocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion.
|
12964013 |
2003 |
|
Adult Acute Myelomonocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion.
|
12964013 |
2003 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
This revealed a tumor suppressor role for Steroid Receptor Coactivator 2/Nuclear Receptor Coactivator 2 (Src-2/Ncoa2) in liver cancer.
|
28273073 |
2017 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Correction: SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
|
29641518 |
2018 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
|
22556267 |
2012 |
|
Adult Rhabdomyosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells.
|
24213582 |
2014 |
|
Adult Rhabdomyosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Awareness of this phenomenon and judicious application of molecular diagnostic testing for the HEY1-NCOA2 fusion are critical to avoid misclassification of mesenchymal chondrosarcoma as rhabdomyosarcoma, with potentially adverse patient impact.
|
29559236 |
2018 |
|
Adult Rhabdomyosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have significantly impacted this classification with the emergence of three distinct new subtypes of rhabdomyosarcomas, namely rhabdomyosarcoma with MYOD1 mutations, rhabdomyosarcoma with TFCP2 fusions, and rhabdomyosarcoma with VGLL2/NCOA2 fusions.
|
31696361 |
2020 |
|
Alkaline phosphatase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Alveolar rhabdomyosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This is the first evidence of occurrence of PAX3-NCOA2 in primary CNS ARMS.
|
31553442 |
2019 |
|
Alveolar rhabdomyosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results may explain why NCOA2 rearrangement is mainly found in embryonal rhabdomyosarcoma, which has a better prognosis than alveolar rhabdomyosarcoma, which expresses the PAX3-FOXO1A fusion gene.
|
24213582 |
2014 |
|
Androgen-Insensitivity Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that residue Q902 is involved in TIF2 and NH2/COOH interaction and that the Q to K mutation results in a mild impairment of AR function, which can explain the partial AIS phenotype of the patient.
|
15486055 |
2005 |
|
Androgen-Insensitivity Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
For the first time, we studied by immunohistochemistry and RT-PCR, the expression and distribution of these two coregulators during human testicular ontogenesis, in patients with altered AR signaling (Androgen insensitivity syndrome, AIS) and evaluated the functional impact of SRC-2 and HBO1 on AR signaling in a Sertoli cell context.
|
23707616 |
2013 |
|
Angiofibroma
|
0.070 |
Biomarker
|
disease |
BEFREE |
We designed an original DNA probe for detecting NCOA2 split signals on fluorescence in situ hybridization (FISH) and estimated its utility with 20 fibrovascular tumors: 4 each of STAs, solitary fibrous tumors (SFTs), and cellular angiofibromas and 3 each of low-grade myxofibrosarcomas, myxoid liposarcomas, and low-grade fibromyxoid sarcomas.
|
24856853 |
2014 |
|
Angiofibroma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The morphologic features are distinct from other sarcomas associated with NCOA2 gene fusions, including mesenchymal chondrosarcoma, congenital/infantile spindle cell rhabdomyosarcoma, and soft tissue angiofibroma.
|
30179902 |
2018 |
|
Angiofibroma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In conclusion, the AHRR-NCOA2 fusion is a frequent finding in soft tissue angiofibroma, while GTF2I-NCOA2 seems to be a rare genetic event.
|
28639284 |
2017 |
|
Angiofibroma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that, in spite of the recurrence of AHRR‑NCOA2 in angiofibroma of soft tissue, additional genetic events (or fusion genes) might be required for the development of this tumor.
|
27633981 |
2016 |
|
Angiofibroma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Angiofibroma of soft tissue with fibrohistiocytic features and intratumor genetic heterogeneity of NCOA2 gene rearrangement revealed by chromogenic in situ hybridization: a case report.
|
24888778 |
2014 |
|
Angiofibroma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.
|
22337624 |
2012 |