NCOA2, nuclear receptor coactivator 2, 10499

N. diseases: 95; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206731
Disease: Angiofibroma
Angiofibroma 		0.070 Biomarker disease BEFREE A solitary fibrous tumor-mimicking tumor with the AHRR-NCOA2 gene has been isolated as angiofibroma of soft tissue. 28759137 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 Biomarker disease CTD_human Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. 20332317 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 Biomarker disease BEFREE However, the transcriptional role of SRC-2 in breast cancer is still ambiguous. 30048685 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 AlteredExpression disease BEFREE As the members of the p160/nuclear receptor co-activator (NCOA) family, NCOA1, NCOA2 and NCOA3 are known to be overexpressed in breast cancer and essentially involved in estrogen-mediated cancer cell proliferation we asked if these proteins are involved in the ERα-mediated transactivation of PLAC1 in breast cancer cells. 24304549 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 Biomarker disease BEFREE Genes of known importance in breast cancer and estrogen signaling, including ERBB2, PGR, MYC, CLU, and NCOA2, were among those identified as Sin3A-responsive. 20920219 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 Biomarker disease BEFREE In conclusion, our results suggest NCOA2 as a potential target of therapeutics against breast cancer. 30941313 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 AlteredExpression disease BEFREE Amplified in breast cancer (AIB1 or SRC-3) is an estrogen receptor coregulatory protein that together with other co-activators like transcription intermediary factor 2 (TIF2) and nuclear receptor co-repressor (NCoR), is implicated in estrogen signaling pathway and estrogen regulated tumor progression. 18521745 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 Biomarker disease BEFREE Collectively, these data indicate that SRC control of basal and hormone-regulated proliferations is not solely mediated by ERα, and suggest that targeting growth inhibition by disrupting SRC-2 and SRC-3 function may be an effective approach to inhibit the growth of tamoxifen-resistant breast cancer. 21059860 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE Moreover, deletion of Ncoa2/Src-2 in mice predisposes to diethylnitrosamine-induced liver tumorigenesis. 22556267 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE We demonstrate that activation of SHP (Small Heterodimer Partner), DKK4 (Dickkopf-4), and CADM4 (Cell Adhesion Molecule 4) by SRC-2 suppresses tumorigenesis in vitro and in vivo. 28273073 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE The pathogenetic mechanisms behind this nonrandom involvement are unknown, but the presence on 8q of two genes, HEY1 and NCOA2, now known to be involved in mesenchymal chondrosarcoma tumorigenesis is, of course, suggestive. 24839999 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE As a member of the p160 steroid receptor coactivator (SRC) family, nuclear receptor coactivator 2 (NCOA2) is known to play essential roles in many physiological and pathological processes, including development, endocrine regulation, and tumorigenesis. 30941313 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 Biomarker phenotype BEFREE These results indicate that the PAX3-NCOA2 fusion gene has a dual role in the tumorigenesis of RMS: promotion of the proliferation and inhibition of the myogenic differentiation of RMS cells. 24213582 2014
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 AlteredExpression disease BEFREE In the present study, we found that (11S)-2α-bromo-3-oxoeudesmano-12,6α-lactone, designated santonin-related compound 2 (SRC2), inhibited NF-κB luciferase reporter activity induced by lymphotoxin β (LTβ) in human lung carcinoma A549 cells. 28966239 2017
CUI: C0220621
Disease: Childhood Acute Myeloid Leukemia
Childhood Acute Myeloid Leukemia 		0.010 GeneticVariation disease BEFREE Childhood acute myeloid leukemia with hemophagocytosis by the blasts and inv(8)(p11q13) with MOZ-TIF2 fusion transcripts. 17805042 2007
CUI: C0279644
Disease: Childhood Acute Myelomonocytic Leukemia
Childhood Acute Myelomonocytic Leukemia 		0.010 GeneticVariation disease BEFREE A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. 12964013 2003
CUI: C0279613
Disease: Childhood Alveolar Rhabdomyosarcoma
Childhood Alveolar Rhabdomyosarcoma 		0.010 Biomarker disease BEFREE Our results may explain why NCOA2 rearrangement is mainly found in embryonal rhabdomyosarcoma, which has a better prognosis than alveolar rhabdomyosarcoma, which expresses the PAX3-FOXO1A fusion gene. 24213582 2014
CUI: C0279612
Disease: Childhood Embryonal Rhabdomyosarcoma
Childhood Embryonal Rhabdomyosarcoma 		0.010 Biomarker disease BEFREE These results indicate that the PAX3-NCOA2 fusion gene has a dual role in the tumorigenesis of RMS: promotion of the proliferation and inhibition of the myogenic differentiation of RMS cells. 24213582 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE In addition, ETV6-NCOA2 leukemia shows a high frequency of heterozygous activating NOTCH1 mutations, which disrupt the heterodimerization or the PEST domains. 18281529 2008
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE These data indicate that MOZ-TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia. 24258712 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE Moreover, induction of AML was suppressed in CSF1R-deficient mice and CSF1R inhibitors slowed the progression of MOZ-TIF2-induced leukemia. 20418886 2010
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE Although leukemia-derived fusion proteins such as MOZ-TIF2 promote self-renewal of leukemic stem cells, recent studies indicate that murine MOZ and MORF are important for proper development of hematopoietic and neurogenic progenitors, respectively, thereby highlighting the importance of epigenetic integrity in safeguarding stem cell identity. 17694082 2007
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 GeneticVariation disease BEFREE This similarity is also apparent at the molecular genetic level, in-as-much as the MOZ gene in 8p11 is rearranged in both the translocation and the inversion; in t(8;16)-positive leukemia, a MOZ-CBP chimeric gene is generated, whereas inv(8) has been shown to generate a MOZ-TIF2 fusion gene. 11342350 2000
CUI: C1332982
Disease: Childhood Mesenchymal Chondrosarcoma
Childhood Mesenchymal Chondrosarcoma 		0.080 Biomarker disease BEFREE The current study adds further support for the use of HEY1-NCOA2 fusion as a valid diagnostic marker for MC. 23252872 2012
CUI: C1332982
Disease: Childhood Mesenchymal Chondrosarcoma
Childhood Mesenchymal Chondrosarcoma 		0.080 GeneticVariation disease BEFREE The transcription factor gene NCOA2 was one of the candidates identified in a mesenchymal chondrosarcoma. 22034177 2012