|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.
|
30570131 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The current study is the first to provide evidence that Met could ameliorate muscle atrophy in high-fat diet induced obesity and this effect may be in part due to regulation of PGC-1α-FoxO3 pathway.
|
30320911 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
To investigate the effects of obesity caused by high-fat diet (HFD) on postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC-1α/FNDC5/BDNF pathway in the hippocampus of older mice.
|
30794116 |
2019 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We tested whether a targeted reduction in hepatic peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which has been shown to occur with obesity, had a negative impact on the metabolic effects of FGF21.
|
29215172 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
BACE1 expression was increased in subcutaneous adipose tissue of obese and type 2 diabetic patients and this was accompanied by a decrease in PGC-1α mRNA levels and by an increase in sAPPβ plasma levels of obese type 2 diabetic patients compared to obese non-diabetic subjects.
|
29526536 |
2018 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
An interaction between ERRα and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) has also recently been shown to regulate an enzyme in the β-oxidation of free fatty acids, thereby suggesting that ERRα plays an important role in obesity and type 2 diabetes.
|
29216352 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, DBT could stimulate phosphorylation of AMPK to raise expression of UCP1 and PGC-1α, and activate thermogenesis to prevent obesity.
|
30258363 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
At least in the subcutaneous fat of humans and mice the levels of PGC-1α decrease during obesity, while its physical association with A20 increases.
|
29678181 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, the transcript and protein levels of transcriptional coactivator peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) and estrogen-related receptor-α (ERRα) in DIO-R mice were significantly up-regulated compared with the DIO mice.
|
28444662 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Special emphasis is placed on the effects of high fat diet (HFD) feeding on expression of nuclear-encoded mitochondrial genes (NEMGs) nuclear receptor factor 1 (NRF-1) and 2 (NRF-2) and peroxisome proliferator receptor gamma coactivator 1 alpha (PGC-1α) in the onset and progression of insulin resistance during obesity and how HFD-induced alterations in NEMG expression affect skeletal muscle mitochondrial adaptations in relation to beta oxidation of fatty acids.
|
28420087 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
|
27473963 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although primarily investigated for its therapeutic potential in obesity and skeletal muscle differentiation, the ability of PGC-1α to alter a multitude of cellular functions has sparked interest in its role in the vasculature.
|
27312223 |
2016 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed.
|
26185753 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to determine the possible association of five single-nucleotide polymorphisms (SNPs) located in the IGF2, LEPR, POMC, PPARG, and PPARGC1 genes with obesity or obesity-related risk phenotypes.
|
25923461 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population.
|
25928419 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies in mice have shown that increased PGC-1α expression may be beneficial or deleterious, depending on the tissue: in adipose tissue, it promotes thermogenesis and thus protects against energy overload, such as seen in diabetes and obesity; in muscle, PGC-1α induces a change of phenotype towards oxidative metabolism.
|
25753246 |
2015 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study aims to test whether 10 polymorphisms in obesity-related genes methionine sulfoxide reductase A (MSRA), transcription factor AP-2 beta (TFAP2B), melanocortin 4 receptor (MC4R), neurexin 3 (NRXN3), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), transmembrane protein 18 (TMEM18), homolog of S. cerevisiae Sec16 (SEC16B), homeobox B5 (HOXB5) and olfactomedin 4 (OLFM4) are associated with the risk of obesity in Portuguese children.
|
24670271 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review, we outline the function of PGC-1 coactivators in physiological and pathological conditions as well as the complex interplay of metabolic dysregulation and inflammation in obesity with special focus on skeletal muscle.
|
24258516 |
2014 |
|
Obesity
|
0.300 |
Therapeutic
|
disease |
RGD |
Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers.
|
23256146 |
2013 |
|
Obesity
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Using bisulfite sequencing, we show that promoter methylation of PGC-1α and PDK4 is altered with obesity and restored to nonobese levels after RYGB-induced weight loss.
|
23583180 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity.
|
22401878 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent studies report that PGC-1α-null mice develop late-onset obesity and that the neuronal inactivation of PGC-1α causes increased food intake.
|
22016516 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We confirm the role of PPARGC1A in muscle and show some support for inflammation in adipose from European American subjects but find prominent roles for lipid metabolism in insulin sensitivity independent of obesity in both tissues.
|
21266331 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
PGC-1α has been implicated in the pathogenic conditions including obesity, type 2 diabetes, neurodegeneration, and cardiomyopathy, whereas PGC-1β plays an important role in plasma lipoprotein homeostasis and serves as a hepatic target for niacin, a potent hypotriglyceridemic drug.
|
21325336 |
2011 |