|
Multiple Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Impact of vitamin A supplementation on RAR gene expression in multiple sclerosis patients.
|
23955709 |
2013 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms.
|
23969901 |
2013 |
|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms.
|
23969901 |
2013 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FXR was expressed in 48 of 59 esophageal adenocarcinoma tissues (81.3%), and this overexpression was associated with higher tumor grade, larger tumor size, and lymph node metastasis; however, was inversely associated with retinoic acid receptor-β2 (RAR-β2 ) expression.
|
23280144 |
2013 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Combined use of RAR-β2 gene promoter methylation, hyaluronidase activity and VUC is promising non-invasive tool for bladder cancer detection.
|
22286019 |
2012 |
|
Bladder Neoplasm
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Combined use of RAR-β2 gene promoter methylation, hyaluronidase activity and VUC is promising non-invasive tool for bladder cancer detection.
|
22286019 |
2012 |
|
Schistosomiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The full-length cDNA sequence of SjTHRβ, its gene organization, and its transcript levels were characterized, and the phylogenetic relationship between THR, RAR and RXR from other organisms were analysis, the ability of this protein binding to a conserved DNA core motif, and its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice were evaluated.
|
22889153 |
2012 |
|
Human papilloma virus infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate: (1) the promoter methylation status of DAPK1, RAR-β2 and MGMT in randomly selected normal cytology of the general female population; (2) the effectiveness of gene methylation in liquid-based cytology to help in the early diagnosis of HSIL; (3) the relationship between HPV infection and gene methylation.
|
22116316 |
2012 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Unphosphorylated c-Myc interacts with RARα to repress the expression of RAR targets required for differentiation, thereby aggravating leukemia malignancy.
|
22510570 |
2012 |
|
Meningomyelocele
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
RAR genes were associated with risk for MM.
|
21254357 |
2011 |
|
Fibroadenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings showed that RAR-β2 expression was lower in the breast cancer compared to normal tissue and fibroadenoma.
|
20865461 |
2011 |
|
precancerous lesions
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
The methylation rate of RAR-β2 in breast cancer and precancerous lesions of breast cancer were higher than that of normal tissues.
|
20865461 |
2011 |
|
Invasive Carcinoma
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In order to investigate the methylation status of the retinoic acid receptor beta 2 gene (RAR-β2) in breast carcinoma in relation to gene expression and clinicopathological parameters of patients with breast cancer, expression of RAR-β2 gene and methylation status were analyzed in invasive carcinoma, atypical ductal hyperplasia, fibroadenoma specimens, and normal tissues.
|
20865461 |
2011 |
|
Skin Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Expression of the PMLRARalpha fusion dominant-negative oncogene in the epidermis of transgenic mice resulted in spontaneous skin tumors attributed to changes in both the PML and RAR pathways [Hansen et al., Cancer Res 2003; 63:5257-5265].
|
19058256 |
2009 |
|
Ichthyosis, X-Linked
|
0.010 |
Biomarker
|
disease |
BEFREE |
Synovial sarcomas, myxoid/round-cell liposarcomas, and gastrointestinal stromal tumors clustered tightly within the former cluster and discriminatory signatures for these were characterized by developmental genes from the EGFR, FGFR, Wnt, Notch, Hedgehog, RAR and KIT signaling pathways.The more pleomorphic STS subtypes, e.g. leiomyosarcoma, malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma and dedifferentiated/pleomorphic liposarcoma, were part of the latter cluster and were characterized by relatively heterogeneous profiles, although subclusters herein were identified.
|
17359542 |
2007 |
|
Hyperactive behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
A strong correlation (p<0.01) was found between hyper-methylation and reduced expression of RAR beta2, however the allelic loss at 3p24, the locus of RAR beta, did not considerably influence its mRNA level.
|
17549354 |
2007 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
Biomarker
|
disease |
BEFREE |
RAR beta2 suppression in head and neck squamous cell carcinoma correlates with site, histology and age.
|
17549354 |
2007 |
|
Steroid Sulfatase Deficiency Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Synovial sarcomas, myxoid/round-cell liposarcomas, and gastrointestinal stromal tumors clustered tightly within the former cluster and discriminatory signatures for these were characterized by developmental genes from the EGFR, FGFR, Wnt, Notch, Hedgehog, RAR and KIT signaling pathways.The more pleomorphic STS subtypes, e.g. leiomyosarcoma, malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma and dedifferentiated/pleomorphic liposarcoma, were part of the latter cluster and were characterized by relatively heterogeneous profiles, although subclusters herein were identified.
|
17359542 |
2007 |
|
ATRICHIA WITH PAPULAR LESIONS
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.
|
16504291 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Bipolar Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Borderline Personality Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Bronchopulmonary Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We conclude that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia.
|
15635645 |
2005 |