RNF139, ring finger protein 139, 11236

N. diseases: 36; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease HPO
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease CTD_human
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker disease CTD_human
CUI: C1266042
Disease: Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1266043
Disease: Sarcomatoid Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1266044
Disease: Collecting Duct Carcinoma of the Kidney
Collecting Duct Carcinoma of the Kidney 		0.300 Biomarker disease CTD_human
CUI: C1306837
Disease: Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1333985
Disease: Hereditary clear cell renal cell carcinoma
Hereditary clear cell renal cell carcinoma 		0.300 FusionGene disease ORPHANET
CUI: C1853237
Disease: Isolated cases
Isolated cases 		0.100 Biomarker phenotype HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE On the basis of its chromosomal position, HRCA1 may be a candidate tumor suppressor gene. 7690964 1993
CUI: C0023521
Disease: Globoid cell leukodystrophy
Globoid cell leukodystrophy 		0.010 Biomarker disease BEFREE Ultrastructurally immunogold deposits only of RCA-I and WGA in the typical Krabbe's inclusions have been clearly demonstrated. 1335383 1993
CUI: C1840423
Disease: HEREDITARY RENAL CANCER ASSOCIATED 1
HEREDITARY RENAL CANCER ASSOCIATED 1 		0.010 Biomarker disease BEFREE We have identified a gene, referred to as HRCA1 (hereditary renal cancer associated 1), that maps immediately adjacent to the breakpoint. 7690964 1993
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.020 Biomarker disease BEFREE We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched. 9689122 1998
CUI: C3811653
Disease: Experimental Organism Basal Cell Carcinoma
Experimental Organism Basal Cell Carcinoma 		0.010 Biomarker phenotype BEFREE We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched. 9689122 1998
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. 12032852 2002
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. 12032852 2002
CUI: C0238462
Disease: Medullary carcinoma of thyroid
Medullary carcinoma of thyroid 		0.010 GeneticVariation disease BEFREE We previously reported that the TRC8 gene was interrupted by a t(3;8) translocation in a family with hereditary renal and non-medullary thyroid cancer. 12032852 2002
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. 15735686 2005
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. 15735686 2005
CUI: C2608055
Disease: Hereditary Renal Cell Carcinoma
Hereditary Renal Cell Carcinoma 		0.010 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C2826323
Disease: Refractory Cytopenia of Childhood
Refractory Cytopenia of Childhood 		0.010 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 GeneticVariation disease BEFREE A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. 17539022 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages. 17539022 2007