RNF139, ring finger protein 139, 11236

N. diseases: 36; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease HPO
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease CTD_human
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 GeneticVariation disease BEFREE A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. 17539022 2007
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker disease CTD_human
CUI: C1266042
Disease: Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1266043
Disease: Sarcomatoid Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1266044
Disease: Collecting Duct Carcinoma of the Kidney
Collecting Duct Carcinoma of the Kidney 		0.300 Biomarker disease CTD_human
CUI: C1306837
Disease: Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1333985
Disease: Hereditary clear cell renal cell carcinoma
Hereditary clear cell renal cell carcinoma 		0.300 FusionGene disease ORPHANET
CUI: C1853237
Disease: Isolated cases
Isolated cases 		0.100 Biomarker phenotype HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 GeneticVariation group BEFREE As the tumor suppressor gene TRC8/RNF139 is disrupted by constitutional t(8;22)(q24.13;q11.21) in dysgerminoma, it may be associated with the onset of CML. 27686674 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Studies have shown that TRC8 exhibits a tumor-suppressive effect through its E3-ligase activity. 22689053 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas. 19642973 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages. 17539022 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Tumor formation in a nude mouse model is inhibited by TRC8 in a RING-dependent manner. 17016439 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE On the basis of its chromosomal position, HRCA1 may be a candidate tumor suppressor gene. 7690964 1993
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 GeneticVariation disease BEFREE The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase. 22689053 2013
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 GeneticVariation disease BEFREE The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase. 22689053 2013
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. 17016439 2007
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. 17016439 2007
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. 15735686 2005
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. 15735686 2005
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. 12032852 2002