|
Hemangioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A Novel RNF139 Mutation in Hemangioblastomas: Case Report.
|
31031691 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
The effect of RNF139 on tumorigenicity of tongue cancer cells was analyzed by xenograft model on immunodeficient Balb/c nude mice.
|
28662643 |
2017 |
|
Myeloid Leukemia, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As the tumor suppressor gene TRC8/RNF139 is disrupted by constitutional t(8;22)(q24.13;q11.21) in dysgerminoma, it may be associated with the onset of CML.
|
27686674 |
2017 |
|
Malignant neoplasm of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
The effect of RNF139 on tumorigenicity of tongue cancer cells was analyzed by xenograft model on immunodeficient Balb/c nude mice.
|
28662643 |
2017 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
In order to find the oral cancer related E3 ubiquitin ligases, we screened the human E3 ubiquitin ligase library and found that RING finger protein 139 (RNF139) regulated the biological behavior of tongue cancer cells.
|
28662643 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In order to find the oral cancer related E3 ubiquitin ligases, we screened the human E3 ubiquitin ligase library and found that RING finger protein 139 (RNF139) regulated the biological behavior of tongue cancer cells.
|
28662643 |
2017 |
|
Tongue Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
While human tongue cancer tissues had low expression of RNF139.
|
28662643 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of the HCV core protein alters endoplasmic reticulum (ER) distribution and induces ER stress in SPP/TRC8 double-knockout cells.
|
27142248 |
2016 |
|
Barrett Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among these proteins, the RNF32 and RNF121 expression in BE was 20.3-fold and 16.4-fold higher, respectively, than that in NE, and the expression of RNF24, RNF130, RNF141, RNF139, RNF11, RNF14, and RNF159 was upregulated more than 2-fold compared with NE.
|
25228972 |
2014 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results highlight the tumorigenic role of HO-1 and the importance of TRC8-mediated HO-1 degradation in the control of cancer growth.
|
22689053 |
2013 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
|
22689053 |
2013 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic TRC8 expression suppresses HO-1-induced cancer cell growth and migration/invasion.
|
22689053 |
2013 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These results highlight the tumorigenic role of HO-1 and the importance of TRC8-mediated HO-1 degradation in the control of cancer growth.
|
22689053 |
2013 |
|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRC8 has the potential to act in a novel regulatory relationship linking the cholesterol/lipid biosynthetic pathway with cellular growth control and has been identified in families with hereditary renal (RCC) and thyroid cancers.
|
19642973 |
2009 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas.
|
19642973 |
2009 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRC8 has the potential to act in a novel regulatory relationship linking the cholesterol/lipid biosynthetic pathway with cellular growth control and has been identified in families with hereditary renal (RCC) and thyroid cancers.
|
19642973 |
2009 |
|
Hereditary Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC).
|
15735686 |
2005 |
|
Refractory Cytopenia of Childhood
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC).
|
15735686 |
2005 |
|
Medullary carcinoma of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We previously reported that the TRC8 gene was interrupted by a t(3;8) translocation in a family with hereditary renal and non-medullary thyroid cancer.
|
12032852 |
2002 |
|
Experimental Organism Basal Cell Carcinoma
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched.
|
9689122 |
1998 |
|
Globoid cell leukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ultrastructurally immunogold deposits only of RCA-I and WGA in the typical Krabbe's inclusions have been clearly demonstrated.
|
1335383 |
1993 |
|
HEREDITARY RENAL CANCER ASSOCIATED 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have identified a gene, referred to as HRCA1 (hereditary renal cancer associated 1), that maps immediately adjacent to the breakpoint.
|
7690964 |
1993 |
|
Dysgerminoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
As the tumor suppressor gene TRC8/RNF139 is disrupted by constitutional t(8;22)(q24.13;q11.21) in dysgerminoma, it may be associated with the onset of CML.
|
27686674 |
2017 |
|
Dysgerminoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
TRC8 was strongly underexpressed in the dysgerminoma.
|
19642973 |
2009 |
|
Clear-cell metastatic renal cell carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Haploinsufficiency of TRC8 may facilitate development of clear cell-RCC in association with VHL mutations, and may increase risk for other tumor types.
|
19642973 |
2009 |