|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).
|
24505444 |
2014 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results show that nicotine dependence is a mediator of the association between lung adenocarcinoma and gene variations in the regions of CHRNA5/A3/B4 and accounts for approximately 15% of this relationship.
|
25233467 |
2014 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Minor allele carriers at rs16969968 in the nicotinic acetylcholine receptor α5 subunit gene (CHRNA5) have been shown to exhibit both reduced cognitive control and greater nicotine dependence.
|
24934182 |
2014 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association and large cohort studies have consistently linked several single nucleotide polymorphisms (SNPs) located in the CHRNA5/A3/B4 gene cluster to smoking behaviors and nicotine dependence.
|
25297392 |
2014 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the CHRNA5-A3-B4 gene cluster have been shown to be associated with nicotine dependence and alcohol use disorders (AUDs) and related traits, including the level of response (LR) to alcohol.
|
23458267 |
2013 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several genetic variants within the nicotinic cholinergic receptor gene cluster, CHRNA5-CHRNA3-CHRNB4 have been reported to be associated with nicotine dependence (ND), and this association has been validated in multiple studies.
|
22884254 |
2013 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.
|
22241830 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report for the first time the relationship between the polymorphism of the CHRNA5 gene and the strength of nicotine addiction measured by multiple factors including the Fagerström test score.
|
21955800 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover variants on the gene cluster CHRNA3-CHRNB4-CHRNA5 are associated with nicotine addiction antismoking therapy and antismoking therapy side-effects.
|
23061658 |
2012 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
The CHRNA5-A3-B4 gene cluster in nicotine addiction.
|
21968931 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic risks of nicotine dependence associated with the CHRNA5-A3-B4 subunit genes are specific, and not shared among commonly comorbid psychiatric disorders.
|
22336398 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified common variation in the CHRNA5-CHRNA3-CHRNB4 and CHRNA6-CHRNB3 gene clusters that contribute to nicotine dependence.
|
22042774 |
2012 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
CPD is an important simple measure that captures in part the genetic associations of CHRNA5 and nicotine dependence, even when other more comprehensive measures of smoking behaviors are examined.
|
22102629 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple studies have provided evidence for genetic associations between single nucleotide polymorphisms (SNPs) located on the CHRNA5/A3/B4 gene cluster and various phenotypes related to Nicotine Dependence (Greenbaum et al.2009).
|
22382757 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One CHRNA5 (rs16969968) and two CHRNA3 (rs1051703, rs6495308) SNPs were examined for their ability to predict smokers who "ever" reported ND based on three phenotypic classifications: (1) 25+ CPD, (2) TTF < 10 min, and (3) HSI ≥ 4.
|
22223462 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A nonsynonymous SNP in CHRNA5 previously associated to ND and several related traits, rs16969968, was genotyped in 2206 EAs (1301 men and 905 women).
|
22012472 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome wide association studies revealed a relationship between development of nicotine dependence and a single-nucleotide polymorphism (SNP, rs16969968) of the nicotine acetylcholine receptor (nAChR) alpha-5 subunit gene (CHRNA5).
|
21764527 |
2012 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study provides the first in vivo evidence of the involvement of the CHRNA5/A3/B4 genomic cluster in nicotine addiction through modifying the activity of brain regions responsible for the balance between the rewarding and the aversive properties of this drug.
|
22101982 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to analyse the association of smoking status and smoking-related phenotypes (included nicotine dependence) with 17 candidate genetic variants: CYP2A6*1×2, CYP2A6*2 (1799T>A) [rs1801272], CYP2A6*9 (-48T>G) [rs28399433], CYP2A6*12, CYP2A13*2 (3375C>T) [rs8192789], CYP2A13*3 (7520C>G), CYP2A13*4 (579G>A), CYP2A13*7 (578C>T) [rs72552266], CYP2B6*4 (785A>G), CYP2B6*9 (516G>T), CHRNA3 546C>T [rs578776], CHRNA5 1192G>A [rs16969968], CNR1 3764C>G [rs6928499], DRD2-ANKK1 2137G>A (Taq1A) [rs1800497], 5HTT LPR, HTR2A -1438A>G [rs6311] and OPRM1 118A>G [rs1799971].
|
22046326 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR).
|
21555077 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs in the CHRNA5 and CHRNA3 receptor genes, previously shown to be significantly associated with ND in this sample, were replicated in the augmented analyses; they accounted for less than one percent of the genetic variance in liability to ND, which is estimated to be over 50% of the phenotypic variance.
|
21748402 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the basis of known associations with nicotine dependence, we genotyped eight single-nucleotide polymorphisms (SNPs) on chromosome 8 (three bins) in the regions of CHRNB3 and CHRNA6, and six SNPs on chromosome 15 (three bins) in the regions of CHRNA5 and CHRNA3.
|
21191315 |
2011 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer.
|
20700147 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |