CNTF, ciliary neurotrophic factor, 1270

N. diseases: 114; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease BEFREE These results call in question the hypothesis that either BDNF or CNTF can be used as molecular markers for depression or late onset depression in the elderly. 16797081 2006
CUI: C4551993
Disease: Amyotrophic Lateral Sclerosis, Familial
Amyotrophic Lateral Sclerosis, Familial 		0.320 Biomarker disease CTD_human Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. 11951178 2002
CUI: C4551993
Disease: Amyotrophic Lateral Sclerosis, Familial
Amyotrophic Lateral Sclerosis, Familial 		0.320 GeneticVariation disease BEFREE Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. 11951178 2002
CUI: C4551993
Disease: Amyotrophic Lateral Sclerosis, Familial
Amyotrophic Lateral Sclerosis, Familial 		0.320 GeneticVariation disease BEFREE Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis. 8543936 1995
CUI: C1862939
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 1 		0.310 Biomarker disease CTD_human Screening for candidate modifier genes that might be responsible for the early onset and severe course of the disease in the 25-year-old patient revealed an additional homozygous mutation of the CNTF gene not found in his yet unaffected sister. hSOD-1G93A mice were crossbred with CNTF(-/-) mice and were investigated with respect to disease onset and duration, to test the hypothesis that CNTF acts as a candidate modifier gene in FALS with mutations in the SOD-1 gene. 11951178 2002
CUI: C1862939
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 1 		0.310 Biomarker disease BEFREE Screening for candidate modifier genes that might be responsible for the early onset and severe course of the disease in the 25-year-old patient revealed an additional homozygous mutation of the CNTF gene not found in his yet unaffected sister. hSOD-1G93A mice were crossbred with CNTF(-/-) mice and were investigated with respect to disease onset and duration, to test the hypothesis that CNTF acts as a candidate modifier gene in FALS with mutations in the SOD-1 gene. 11951178 2002
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.310 Biomarker disease CTD_human Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. 11951178 2002
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.310 GeneticVariation disease BEFREE In addition, patients with sporadic amyotrophic lateral sclerosis who had a homozygous CNTF gene defect showed significantly earlier disease onset but did not show a significant difference in disease duration. 11951178 2002
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 GeneticVariation disease BEFREE We failed to detect an earlier onset of HD in nine homozygotes and 71 heterozygotes with this CNTF mutation compared with 203 homozygotes with wild-type alleles. 9305364 1997
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Our results show that human CNTF has a trophic influence on degenerating striatal neurons as well as on critical non-striatal regions such as the cerebral cortex, supporting the idea that human CNTF may help to prevent the degeneration of vulnerable striatal populations and cortical-striatal basal ganglia circuits in Huntington's disease. 9121555 1997
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE In the present work, we used tetracycline (Tet)-regulated lentiviral vectors to investigate the dose-dependent neuroprotective effect of human ciliary neurotrophic factor (CNTF) in the quinolinic acid (QA) model of Huntington's disease (HD). 12427308 2002
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Proteins with neuroprotective effects in the adult brain have been identified, among them ciliary neurotrophic factor (CNTF), which protected striatal neurons in animal models of HD. 15585112 2004
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 AlteredExpression disease BEFREE Further studies are, however, needed to investigate the intracellular signaling pathways mediating the long-term effects of CNTF expression on dopamine signaling, glial cell activation and how these changes may affect HD pathology. 14697316 2004
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. 9171158 1997
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE These results support the hypothesis that CNTF infusion into the striatum of HD patients not only could block the degeneration of neurons but also alleviated motor and cognitive symptoms associated with persistent neuronal dysfunction. 10834619 2000
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Intracerebral administration of CNTF and CNTF analogs has also been shown to protect striatal output neurons in rodent and primate models of Huntington's disease. 10812968 2000
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease RGD We explored the potential of adenovirus-mediated gene transfer to fulfill these requirements by studying the functional and anatomical effects of single-site striatal delivery of CNTF recombinant vectors in a rat model of HD. 12040055 2002
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 AlteredExpression disease LHGDN Wild-type and R6/1 HD transgenic (R6/1) mice that received bilateral or unilateral intrastriatal injections of rAAV2-CNTF experienced weight loss. 18293418 2008
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. 10954906 2000
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Cellular delivery of CNTF but not NT-4/5 prevents degeneration of striatal neurons in a rodent model of Huntington's disease. 9588602 1998
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 Biomarker disease BEFREE Intracompartmental delivery of CNTF as therapy for Huntington's disease and retinitis pigmentosa. 16475952 2006
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.300 AlteredExpression disease BEFREE Wild-type and R6/1 HD transgenic (R6/1) mice that received bilateral or unilateral intrastriatal injections of rAAV2-CNTF experienced weight loss. 18293418 2008
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.210 Biomarker disease RGD Immunoblots showed that STAT3 was transiently phosphorylated after IOP increase, but with an injection of CNTF, pSTAT3 protein was observed up to 2 weeks after hypertensive glaucoma induction. 14725620 2004
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.210 Biomarker disease BEFREE The serum CNTF concentration did not show any dependence on the glaucoma stage. 29225456 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.200 Biomarker disease RGD Reduced ciliary neuronotrophic factor-like activity in nerves from diabetic or galactose-fed rats. 1571789 1992