CNTF, ciliary neurotrophic factor, 1270

N. diseases: 114; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. 18303965 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease LHGDN Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. 18303965 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. 18303965 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population. 16969278 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population. 16969278 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE These results suggested that the variations at the NT3 and the CNTF genes do not influence the schizophrenia risk, but a role in the susceptibility of subgroups of the patients cannot be excluded. 15474906 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET These results suggested that the variations at the NT3 and the CNTF genes do not influence the schizophrenia risk, but a role in the susceptibility of subgroups of the patients cannot be excluded. 15474906 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Our results suggest that the polymorphisms at the DRD3, 5HTR2A, CNTF and BDNF gene loci are unlikely to make our sample more genetically susceptible to schizophrenia. 11343865 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Our results suggest that the polymorphisms at the DRD3, 5HTR2A, CNTF and BDNF gene loci are unlikely to make our sample more genetically susceptible to schizophrenia. 11343865 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE We investigated the association between a null mutation in the ciliary neurotrophic factor (CNTF) gene and functional psychoses including schizophrenia and schizoaffective disorder. 9601653 1998
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease. 9342199 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Ciliary neurotrophic factor null mutation and schizophrenia in a Swedish population. 9285965 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Our results did not provide evidence for the involvement of the null mutation of the CNTF gene in the development of schizophrenia. 9247976 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE It is concluded that the CNTF null mutation may be relevant to the aetiopathogenesis of schizophrenia in some patients, but further work is required to identify specifically the patient group for which it is important. 8856688 1996
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease BEFREE This study reveals a novel CNTF-mediated mechanism in stress-induced depressive-like behavior and points to opportunities for sex-specific treatments for depression, e.g. progesterone in females and CNTF-stimulating drugs in males. 30299260 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease BEFREE This study reveals a novel CNTF-mediated mechanism in stress-induced depressive-like behavior and points to opportunities for sex-specific treatments for depression, e.g. progesterone in females and CNTF-stimulating drugs in males. 30299260 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET These data imply that endogenous CNTF plays a pivotal role for the structural maintenance of hippocampal functions and thus has an important impact on the modulation of affective behavior in rodent models of anxiety and depression. 22266927 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET These data imply that endogenous CNTF plays a pivotal role for the structural maintenance of hippocampal functions and thus has an important impact on the modulation of affective behavior in rodent models of anxiety and depression. 22266927 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Associations between AD and/or depression to gene polymorphisms APO E (epsilon4), choline acetyltransferase (ChAT) 4G to A, serotonin-transporter gene promoter-length, dopamine-D4-receptor, ciliary-neurotrophic-factor-null mutation and brain-derived neurotrophic factor (C270T) and to various known factors were analyzed. 18603262 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET Associations between AD and/or depression to gene polymorphisms APO E (epsilon4), choline acetyltransferase (ChAT) 4G to A, serotonin-transporter gene promoter-length, dopamine-D4-receptor, ciliary-neurotrophic-factor-null mutation and brain-derived neurotrophic factor (C270T) and to various known factors were analyzed. 18603262 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET These results call in question the hypothesis that either BDNF or CNTF can be used as molecular markers for depression or late onset depression in the elderly. 16797081 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease BEFREE These results call in question the hypothesis that either BDNF or CNTF can be used as molecular markers for depression or late onset depression in the elderly. 16797081 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET These results call in question the hypothesis that either BDNF or CNTF can be used as molecular markers for depression or late onset depression in the elderly. 16797081 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease BEFREE These results call in question the hypothesis that either BDNF or CNTF can be used as molecular markers for depression or late onset depression in the elderly. 16797081 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET No sign of CNTF-induced toxicity was observed; however, depression occurred in three subjects after removal of the last capsule, which may have correlated with the lack of any future therapeutic option. 15585112 2004