|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
This finding is in the same direction as reported findings on schizophrenia and it adds to the list of evidence that COMT or a nearby gene in linkage disequilibrium is involved in the pathogenesis of the disease.
|
12192614 |
2002 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the present study was to evaluate in patients with schizophrenia the effect of COMT genotype on symptom variation, working memory performance, and prefrontal cortical physiology in response to treatment with an atypical antipsychotic drug.
|
15465976 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia.
|
25600541 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our genetic data suggest that DRD1 and COMT are epistatically associated with protection against and the risk of developing schizophrenia in a gender-dependent fashion, and support the role of dopamine dysfunction at the PFC in the pathophysiology of this disorder.
|
20127886 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
From this work, genetic variation within both the methylenetetrahydrofolate reductase (MTHFR) gene and the catechol-O-methyltransferase (COMT) gene has been associated with an increased risk of metabolic syndrome in schizophrenia patients treated with AAPs.
|
23341251 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Findings suggest that anhedonia is manifest in individuals who carry genetic liability for schizophrenia and is associated with the Val(158)Met polymorphism of the COMT gene.
|
19025226 |
2008 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude by outlining preliminary data indicating that COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia.
|
16476412 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We report that the variation in gene sequence at the four COMT SNPs studied was not associated with an altered the risk of schizophrenia but genotype at rs4680 and rs4818, but not rs165519 and rs737865, were associated with varying levels of cortical CHRM1 expression in the human dorsolateral prefrontal cortex (DLPFC).
|
26954460 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Carriage of a mutant catechol-O-methyltransferase (COMT) allele is associated with breast cancer, neurologic disorders such as Parkinson's disease, and modulates behavior among patients with schizophrenia, alcoholics and the general population.
|
11955795 |
2002 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain.
|
15098000 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that odor identification impairments observed in schizophrenia are influenced by the COMT val158met polymorphism.
|
22148860 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: findings from a large German case-control and family-based sample.
|
20643532 |
2010 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The findings are of translational relevance, because COMT inhibitors are used in the adjunctive treatment of Parkinson's disease and are under evaluation in schizophrenia and other disorders.
|
22364739 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that variation of the COMT gene is associated with treatment response regarding negative symptoms and prolactin changes after amisulpride treatment in patients with schizophrenia.
|
26724569 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene.
|
15668720 |
2005 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia.
|
12799619 |
2003 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
They also point to possible gender differences as to the role of COMT in brain function in schizophrenia.
|
12467945 |
2002 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that epistasis between MAOA and COMT genes may not influence suicidal behavior in patients with schizophrenia.
|
16725119 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the possible epigenetic modulation of the expression of the COMT Val(158)Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.
|
24252819 |
2014 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
These in vivo results suggest that deleterious genotypes for DAOA and COMT might contribute to the pathophysiology of schizophrenia, perhaps through combined glutamatergic and dopaminergic dysregulation.
|
21215384 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia.
|
22901597 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that a functional polymorphism of the catechol-O-methyltransferase (COMT) gene predisposes to an increased risk for schizophrenia and likely to psychosis susceptibility.
|
15488308 |
2004 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
There was a significant interaction between peripheral proline and COMT on negative symptoms in schizophrenia (P<0.0001, n=95).
|
27622935 |
2016 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Searches using PubMed, Web of Science, and PsycInfo databases (03/01/2015) yielded 23 studies investigating COMT Val158Met variation and antipsychotic response in schizophrenia and schizo-affective disorder.
|
26745992 |
2016 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
As COMT and PRODH are both located on chromosome 22q11, the results also argue against the hypothesis that schizophrenia is associated with a decrease in expression of all 22q11 genes, as had been suggested by the high prevalence of psychosis in people with hemizygous 22q11 deletions.
|
14618678 |
2004 |