|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that COMT activity is not an indicator of vulnerability to schizophrenia.
|
6691458 |
1984 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.
|
8561211 |
1996 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that either val-108 is a minor risk factor for schizophrenia, that the COMT gene has additional polymorphisms with greater effect on risk, or that this region of chromosome 22 contains a susceptibility gene which is in linkage disequilibrium with the COMT gene.
|
8902889 |
1996 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support an association between the BglI polymorphism of COMT gene and schizophrenia.
|
8950414 |
1996 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Considering the role of COMT in dopamine metabolism and the involvement of dopaminergic pathways in the pathogenesis of schizophrenia and violence, we screened 37 patients with schizophrenia to determine whether or not a behavioral association with the COMT polymorphism exists.
|
9109174 |
1997 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Overall, these findings may indicate an effect of COMT alleles on susceptibility to schizophrenia, or reflect linkage disequilibrium with a different causative polymorphism in the vicinity.
|
9323320 |
1997 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We address the issue of a direct involvement of the COMT gene in the development of schizophrenia by employing the first extensive mutational analysis of this gene in a sample of 157 schizophrenia patients and 129 healthy controls, using single-strand conformation polymorphism and chemical cleavage methodologies.
|
9532347 |
1998 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated a genetic association between schizophrenia and the COMT gene polymorphism in 150 Japanese schizophrenics and controls.
|
9535125 |
1998 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder.
|
9619160 |
1998 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the COMT gene does not play a major role in the pathogenesis of schizophrenia, and the genotypic overlap between schizophrenia and velocardiofacial syndrome was rare in this cohort.
|
10450274 |
1999 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
This finding suggests a possible minor effect of COMT in a multifactorial threshold model of vulnerability to schizophrenia.
|
10490696 |
1999 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence that possession of the low-activity COMT allele was associated with schizophrenia in our sample of individuals with VCFS.
|
10530637 |
1999 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity.
|
10581481 |
1999 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, there may be a susceptibility gene for schizophrenia in a distinct region from the COMT locus on chromosome 22q, as a genome scan has suggested recently.
|
10697824 |
1999 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The catechol-O-methyltransferase (COMT) gene was thought to be a candidate gene for schizophrenia because of its role in inactivating dopamine.
|
11150892 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Suicidal behavior in patients with schizophrenia is related to COMT polymorphism.
|
11204347 |
2000 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
No evidence for linkage between COMT and schizophrenia in a French population.
|
11368843 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia.
|
11381111 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to assess the relationship of schizophrenia and its subgroups with COMT gene polymorphism.
|
11525417 |
2001 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
CONCLUSIONS; The high-activity COMT homozygote confers a higher risk of recorded aggression in schizophrenia.
|
11581117 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Carriage of a mutant catechol-O-methyltransferase (COMT) allele is associated with breast cancer, neurologic disorders such as Parkinson's disease, and modulates behavior among patients with schizophrenia, alcoholics and the general population.
|
11955795 |
2002 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Carriage of a mutant catechol-O-methyltransferase allele is associated with breast cancer, neurologic disorders such as Parkinson's disease, and modulates behavior among patients with schizophrenia, alcoholics and the general population.
|
12020974 |
2002 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population.
|
12082558 |
2002 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test.
|
12090821 |
2002 |