|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further studies are required to better understand the association of symptomatology of schizophrenia and other psychiatric disorders with COMT gene polymorphism.
|
11525417 |
2001 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This study examined the association of COMT with salivary cortisol across a 1-year period in healthy and at-risk adolescents with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision Axis II diagnoses.
|
20421850 |
2010 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A variation in catechol-O-methyltransferase (COMT) gene (Val(108/158)Met) affects the physiological response of hippocampal-prefrontal circuits, predicts variation in human memory and is associated with increased risk for psychiatric disorders.
|
18287936 |
2008 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Increasing evidence suggests that the catechol-O-methyltransferase (COMT) gene might be associated with cognition in patients with mental disorders and healthy people.
|
24373005 |
2014 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The present study appears to be the first comprehensive meta-analysis of COMT genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables).
|
28608575 |
2018 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Specifically, the Val<sup>158</sup>Met polymorphism greatly alters COMT function and cognitive performance in both psychiatric disorders and healthy controls.
|
30146088 |
2019 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction.
|
17577421 |
2007 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Many association studies have reported associations between the catechol-O-methyltransferase (COMT) gene and psychiatric disorders including major depression (MDD).
|
21940152 |
2012 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The Catechol-O-methyltransferase (COMT) gene has been an important candidate risk factor for several psychiatric disorders.
|
28235603 |
2017 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Many clinical and genomic association studies suggested that the catechol-O-methyltransferase (COMT) gene region was an important genetic locus for psychiatric disorders, because of the proposed relationship between its function in catecholaminergic neurotransmission and individual response to antidepressants, and vulnerability to psychiatric disorders.
|
22483292 |
2012 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The identification of candidate genes for heart anomalies, mental illness, and other clinical phenotypes has been reported in the past year with a focus on TBX1 for cardiac and craniofacial phenotypes and COMT and PRODH for psychiatric disorders.
|
16282778 |
2005 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The COMT gene is probably not "a gene for" any mental disorder, but the Val158Met polymorphism appears to have pleiotropic effects on human behavior.
|
17419009 |
2007 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The relationship between proline and COMT also appears to modify negative symptoms across psychiatric illness.
|
27622935 |
2016 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Future longitudinal studies focusing on additional COMT polymorphic sites and other candidate genes from the deleted region will elucidate the molecular pathways leading to schizophrenia and other psychiatric disorders in VCFS.
|
16734939 |
2007 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
|
24389396 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Due to its role in neurotransmitter flux, multiple COMT variants have been associated with the development of psychiatric disorders.
|
27228319 |
2016 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.
|
16542182 |
2006 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders.
|
20004480 |
2010 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
|
22138198 |
2012 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A common functional polymorphism that results in a three- to four-fold difference in catechol-O-methyltransferase (COMT) enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism (Lachman et al., 1996a; Karayiorgou et al., 1997; Vandenbergh et al., 1997; Papolos et al., 1998; Tiihonen et al., 1999).
|
11204347 |
2000 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia.
|
25283873 |
2015 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
|
27203226 |
2016 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism.
|
10395222 |
1999 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The involvement of the COMT gene in the metabolic pathway of these neurotransmitters has made it an attractive candidate gene for many psychiatric disorders.
|
15124004 |
2004 |