|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further studies are required to better understand the association of symptomatology of schizophrenia and other psychiatric disorders with COMT gene polymorphism.
|
11525417 |
2001 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A variation in catechol-O-methyltransferase (COMT) gene (Val(108/158)Met) affects the physiological response of hippocampal-prefrontal circuits, predicts variation in human memory and is associated with increased risk for psychiatric disorders.
|
18287936 |
2008 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Increasing evidence suggests that the catechol-O-methyltransferase (COMT) gene might be associated with cognition in patients with mental disorders and healthy people.
|
24373005 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Specifically, the Val<sup>158</sup>Met polymorphism greatly alters COMT function and cognitive performance in both psychiatric disorders and healthy controls.
|
30146088 |
2019 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction.
|
17577421 |
2007 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Many association studies have reported associations between the catechol-O-methyltransferase (COMT) gene and psychiatric disorders including major depression (MDD).
|
21940152 |
2012 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Many clinical and genomic association studies suggested that the catechol-O-methyltransferase (COMT) gene region was an important genetic locus for psychiatric disorders, because of the proposed relationship between its function in catecholaminergic neurotransmission and individual response to antidepressants, and vulnerability to psychiatric disorders.
|
22483292 |
2012 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The COMT gene is probably not "a gene for" any mental disorder, but the Val158Met polymorphism appears to have pleiotropic effects on human behavior.
|
17419009 |
2007 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
|
24389396 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Due to its role in neurotransmitter flux, multiple COMT variants have been associated with the development of psychiatric disorders.
|
27228319 |
2016 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.
|
16542182 |
2006 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
|
22138198 |
2012 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia.
|
25283873 |
2015 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
|
27203226 |
2016 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele.
|
18384078 |
2008 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
|
24708432 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.
|
17805313 |
2008 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT gene polymorphism is associated with mental disorders and sensitivity to pain.
|
30881091 |
2019 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The COMT Val<sup>158</sup>Met genotype and PTSD association persists after controlling for race (multivariable OR of 0.29, 95% CI [0.10-0.83]) and pre-existing psychiatric disorders/substance abuse (multivariable OR of 0.32, 95% CI [0.11-0.97]).
|
27769642 |
2017 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Additionally, these findings contribute to the growing literature on sex-specific effects of COMT on the predisposition to psychiatric disorders and personality traits.
|
25722988 |
2015 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT is a known neuropsychiatric candidate gene, which contains a genotype variant (Val<sup>108/158</sup>Met) that affects protein function and has been found associated with several psychiatric disorders.
|
31587837 |
2019 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.
|
17949513 |
2008 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene.
|
21231925 |
2011 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders.
|
10686561 |
2000 |