Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast, COMT Val allele homozygosity was associated with depression (OR = 4.34).
|
29627597 |
2018 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the suggested mood enhancing role of estrogens and the higher prevalence of depression in women, we set out to investigate the potential impact of functional COMT genetic variants on depression and anxiety symptoms in a homogeneous female community sample.
|
23351565 |
2013 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
|
24446536 |
2012 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT was associated with depression following exposure to stressors (chi2=13.05, d.f.=2, p=0.0015) and SERTPR also showed a positive association (chi2=6.70, d.f.=2, p=0.035), mainly among women and among major depressives.
|
16756688 |
2007 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brooding rumination and heart rate variability in women at high and low risk for depression: group differences and moderation by COMT genotype.
|
24661160 |
2014 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be associated with treatment response in depression.
|
17700596 |
2008 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present study supports a potentially gender-specific significant impact of COMT gene variation on electroconvulsive therapy response, with COMT 158val risk allele carriers suffering from more severe, pharmacologically less efficiently treatable depression and thus possibly deriving greater benefit from ECT in the first place.
|
19309019 |
2010 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, variations in the COMT gene exert complex effects on susceptibility to depression involving various intermediate phenotypes, such as impulsivity and executive function.
|
23008195 |
2012 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-based sample of 405 depressed individuals (major depression diagnosis, dysthymia or mixed anxiety depression defined according to DSM-IV) and 2,151 healthy controls.
|
20828831 |
2011 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of candidate variants of COMT with neuroticism, anxiety and depression.
|
18384078 |
2008 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The COMT gene was not associated with cognitive vulnerability or risk for depression.
|
22240101 |
2012 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Simple regression analysis was performed between pain intensity numerical rating scale (NRS) (day 8) as the dependent variable, expectation of pain decrease NRS (day 1), tumor types, and the following covariates as independent variables: patients' characteristics such as age, gender, PS (day 1), genotype of catechol-O-methyltransferase, total scores of Hospital Anxiety and Depression Scale (day 1), and pain intensity NRS (day 1).
|
28265809 |
2017 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
No correlation was found between the changes in COMT activity and the psychopathological picture of depression or the severity of endogenous depressive syndrome.
|
6846043 |
1983 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The functional catechol-O-methyltransferase (COMT) val158met polymorphism has been found to be associated with anxiety disorders and depression as well as with neural correlates of emotional processing, with, however, contradictory results.
|
22387174 |
2012 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested for preferential transmission of COMT alleles from parent to affected offspring (n = 749) for each of the five factor-derived scales (negative symptoms, delusions, hallucinations, mania, and depression).
|
16921496 |
2006 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks.
|
17522626 |
2008 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT and the DAT regulate dopamine availability in the prefrontal cortex and the striatum, respectively, two key regions recruited during learning, whereas dopamine D1 and D2 receptors are thought to be involved in long-term potentiation and depression, respectively.
|
26419600 |
2015 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression.
|
20577990 |
2010 |
Mental Depression
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Differential effect of COMT gene methylation on the prefrontal connectivity in subjects with depression versus healthy subjects.
|
29723539 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we sought to examine the independent and joint contributions of low COMT and stress to chronic functional pain and depression at the behavioral and molecular level.
|
31815911 |
2019 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to examine whether the COMT-MTHFR genotype interacted with cognitive function in late-onset depression (LOD) patients and COMT Val/Val homozygous individuals who also carried the MTHFR T allele and had poor neuropsychological test performance.
|
24373005 |
2014 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) is associated with lower enzymatic activity than the Val allele and is reported to be associated with aggression, depression, and suicidal behavior.
|
18828035 |
2008 |