|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT was associated with depression following exposure to stressors (chi2=13.05, d.f.=2, p=0.0015) and SERTPR also showed a positive association (chi2=6.70, d.f.=2, p=0.035), mainly among women and among major depressives.
|
16756688 |
2007 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Catechol-O-Methyltransferase (COMT) and Methylenetetrahydrofolate reductase (MTHFR) had been reported to relate to depression but with inconsistent results.
|
19235787 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT and the DAT regulate dopamine availability in the prefrontal cortex and the striatum, respectively, two key regions recruited during learning, whereas dopamine D1 and D2 receptors are thought to be involved in long-term potentiation and depression, respectively.
|
26419600 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment.
|
27154305 |
2016 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache.
|
30614828 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis study suggested the link between COMT SNPs and MDD risk; in addition, MB membrane-bound (MB-COMT) specific genetic variation was reported that influences predisposition to depression amongst females.
|
30597299 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
All patients were evaluated by using the Geriatric Depression Scale, disease progression was recorded, and GNβ3 and COMT were genotyped by PCR.
|
25037115 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although some studies indicate a role for COMT in emotionality, anxiety, and depression in adults, no direct effect or interaction of COMT genotype was observed in this large sample of young children.
|
18535998 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the current study found no association between COMT Val(158)Met polymorphism on a number of clinical neuropsychological tests that are typically found to be sensitive to depression, differential effects of the COMT Val(158)Met polymorphism on dopamine transmission in psychiatric and non-psychiatric populations may be further clarified by clinical research with neuroscience-based paradigms that segregate cognitive tasks into component processes with precise neural substrates, particularly with respect to the complex functions of the prefrontal cortex.
|
19296553 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
An interaction with catechol-O-methyltransferase (COMT) has also been proved affecting depression.
|
26021967 |
2015 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of candidate variants of COMT with neuroticism, anxiety and depression.
|
18384078 |
2008 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both additive interaction (attributable proportion (AP) = 0.56; 95% CI: 0.24-0.90 and synergy index (SI) = 4.39; 1.0-18.7) and multiplicative interaction (log likelihood test p = 0.1) was present between depression and COMT Val<sup>158</sup>Met in predicting risk of later CVD.
|
30045690 |
2018 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brooding rumination and heart rate variability in women at high and low risk for depression: group differences and moderation by COMT genotype.
|
24661160 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Brooding rumination and heart rate variability in women at high and low risk for depression: group differences and moderation by COMT genotype.
|
24661160 |
2014 |
|
Mental Depression
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Differential effect of COMT gene methylation on the prefrontal connectivity in subjects with depression versus healthy subjects.
|
29723539 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of gene polymorphisms on clinical improvement were analyzed with an analysis of variance with each gene (SERTPR, 5-HT(1A) , and COMT) as factors and the Hamilton Rating Scale for Depression variation from baseline to the end of the treatment as a dependent variable.
|
21449006 |
2011 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
FEP patients with depression showed increased COMT expression and decreased NDEL1 expression.
|
26491028 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further stratification based on gender revealed an isolated effect of the COMT genotype in males (P=0.035) but not in females (P=0.650) in percent reduction in HAM-D(21) scores in the eighth week.
|
18533273 |
2009 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the subdivision into two subpopulations, one with normal COMT activity and another with lower COMT activity, did not make it possible to assign a role to the enzyme in the severity of depression.
|
3478963 |
1987 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genotypes for the COMT Val158Met and DRD4 VNTR-48 polymorphisms and TCI Harm Avoidance and MMPI Depression scales' scores were obtained as well.
|
25011686 |
2014 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the suggested mood enhancing role of estrogens and the higher prevalence of depression in women, we set out to investigate the potential impact of functional COMT genetic variants on depression and anxiety symptoms in a homogeneous female community sample.
|
23351565 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we sought to examine the independent and joint contributions of low COMT and stress to chronic functional pain and depression at the behavioral and molecular level.
|
31815911 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, variations in the COMT gene exert complex effects on susceptibility to depression involving various intermediate phenotypes, such as impulsivity and executive function.
|
23008195 |
2012 |