|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
No correlation was found between the changes in COMT activity and the psychopathological picture of depression or the severity of endogenous depressive syndrome.
|
6846043 |
1983 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the subdivision into two subpopulations, one with normal COMT activity and another with lower COMT activity, did not make it possible to assign a role to the enzyme in the severity of depression.
|
3478963 |
1987 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested for preferential transmission of COMT alleles from parent to affected offspring (n = 749) for each of the five factor-derived scales (negative symptoms, delusions, hallucinations, mania, and depression).
|
16921496 |
2006 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT was associated with depression following exposure to stressors (chi2=13.05, d.f.=2, p=0.0015) and SERTPR also showed a positive association (chi2=6.70, d.f.=2, p=0.035), mainly among women and among major depressives.
|
16756688 |
2007 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the 22q11.2 deletion syndrome group, baseline subthreshold psychotic symptoms interacted both with the COMT genotype and with baseline symptoms of anxiety or depression to predict 61% of the variance in severity of psychosis at follow-up evaluation.
|
17403981 |
2007 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be associated with treatment response in depression.
|
17700596 |
2008 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of candidate variants of COMT with neuroticism, anxiety and depression.
|
18384078 |
2008 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks.
|
17522626 |
2008 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) is associated with lower enzymatic activity than the Val allele and is reported to be associated with aggression, depression, and suicidal behavior.
|
18828035 |
2008 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of > or = 8.
|
18578865 |
2008 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Catechol-O-Methyltransferase (COMT) and Methylenetetrahydrofolate reductase (MTHFR) had been reported to relate to depression but with inconsistent results.
|
19235787 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the current study found no association between COMT Val(158)Met polymorphism on a number of clinical neuropsychological tests that are typically found to be sensitive to depression, differential effects of the COMT Val(158)Met polymorphism on dopamine transmission in psychiatric and non-psychiatric populations may be further clarified by clinical research with neuroscience-based paradigms that segregate cognitive tasks into component processes with precise neural substrates, particularly with respect to the complex functions of the prefrontal cortex.
|
19296553 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although some studies indicate a role for COMT in emotionality, anxiety, and depression in adults, no direct effect or interaction of COMT genotype was observed in this large sample of young children.
|
18535998 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further stratification based on gender revealed an isolated effect of the COMT genotype in males (P=0.035) but not in females (P=0.650) in percent reduction in HAM-D(21) scores in the eighth week.
|
18533273 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present study supports a potentially gender-specific significant impact of COMT gene variation on electroconvulsive therapy response, with COMT 158val risk allele carriers suffering from more severe, pharmacologically less efficiently treatable depression and thus possibly deriving greater benefit from ECT in the first place.
|
19309019 |
2010 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression.
|
20577990 |
2010 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-based sample of 405 depressed individuals (major depression diagnosis, dysthymia or mixed anxiety depression defined according to DSM-IV) and 2,151 healthy controls.
|
20828831 |
2011 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of gene polymorphisms on clinical improvement were analyzed with an analysis of variance with each gene (SERTPR, 5-HT(1A) , and COMT) as factors and the Hamilton Rating Scale for Depression variation from baseline to the end of the treatment as a dependent variable.
|
21449006 |
2011 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since pain syndromes as well as anxiety and depression are associated to low and high COMT activity respectively and these conditions are all associated with irritable bowel syndrome (IBS) we wanted for the first time to explore the relationship between the polymorphism and IBS.
|
21437260 |
2011 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
|
24446536 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, variations in the COMT gene exert complex effects on susceptibility to depression involving various intermediate phenotypes, such as impulsivity and executive function.
|
23008195 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The COMT gene was not associated with cognitive vulnerability or risk for depression.
|
22240101 |
2012 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The functional catechol-O-methyltransferase (COMT) val158met polymorphism has been found to be associated with anxiety disorders and depression as well as with neural correlates of emotional processing, with, however, contradictory results.
|
22387174 |
2012 |