|
Attention deficit hyperactivity disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
Altogether, the present findings suggested that the ADORA2A gene and the interaction of ADORA2A and DRD2 genes may play a role in anxiety disorders in children and adolescents with ADHD.
|
30946941 |
2019 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the current edition, Fujioka and colleagues report on four Japanese patients with Parkinson disease (PD) and severe postural abnormalities treated with istradefylline (adenosine A2A receptor antagonist); further, dopamine agonists were with- drawn.
|
31469906 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wild-type and Adora2a-deficient mouse KRN T cell receptor-transgenic CD4 T cells specific for glucose-6-phosphate isomerase (GPI)/I-A<sup>g7</sup> were transferred into immunodeficient Tcra<sup>-/-</sup> I-A<sup>g7</sup> -expressing mice to induce arthritis.
|
30516351 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Wild-type and Adora2a-deficient mouse KRN T cell receptor-transgenic CD4 T cells specific for glucose-6-phosphate isomerase (GPI)/I-A<sup>g7</sup> were transferred into immunodeficient Tcra<sup>-/-</sup> I-A<sup>g7</sup> -expressing mice to induce arthritis.
|
30516351 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adenosine interaction with adenosine receptor A2a promotes gastric cancer metastasis by enhancing PI3K-AKT-mTOR signaling.
|
31339445 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Adora2a-mediated signaling in vascular endothelial cells disrupts the BBB in dietary obesity, and implicate cerebrovascular dysfunction as the underlying mechanism for deficits in synaptic plasticity and cognition with obesity and insulin resistance.<b>SIGNIFICANCE STATEMENT</b> The blood-brain barrier (BBB) restricts the entry of circulating factors into the brain, but obesity promotes BBB breakdown in humans and animal models.
|
30886019 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Mice specifically deficient in endothelial Adora2a (Adora2a<sup>ΔVEC</sup> ) showed reduced leukocyte infiltration, BBB leakage, and oedema after stroke, along with attenuated downstream proinflammatory markers, both in vivo and in vitro.
|
30931525 |
2019 |
|
Synovitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis.
|
30956681 |
2019 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance.
|
30886019 |
2019 |
|
Depressive episode, unspecified
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we examined an association between a single nucleotide polymorphism in A<sub>2A</sub> receptor gene (ADORA2A, rs2298383 SNP) with current depressive episode and symptom profile.
|
30511252 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis.
|
31413909 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Adenosine interaction with adenosine receptor A2a promotes gastric cancer metastasis by enhancing PI3K-AKT-mTOR signaling.
|
31339445 |
2019 |
|
Thromboembolic stroke
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thromboembolic stroke induced Adora2a expression in the brain.
|
30931525 |
2019 |
|
Anxiety Disorders
|
0.390 |
Biomarker
|
group |
BEFREE |
CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.
|
30248915 |
2018 |
|
Depressive disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Interestingly, paired-pulse depression was similarly sensitive to disruption by ATP P2Y and adenosine A2A receptor antagonists.
|
29277734 |
2018 |
|
Depressive disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy.
|
29761007 |
2018 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Long-term Outcome of Adenosine A2A Receptor Antagonist on Lower Urinary Tract Symptoms in Male Parkinson Disease Patients.
|
29672326 |
2018 |
|
Caffeine related disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Using genetic and candidate gene approaches, we show that among a variety of protein, Wls interacts with the dopamine transporter (target of cocaine), cannabinoid receptors (target of THC), Adenosine A2A receptor (target of caffeine), and SGIP1 (endocytic regulator of cannabinoid receptors).
|
28734904 |
2018 |
|
Caffeine related disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here, we briefly review the drivers of this inter-individual variation in caffeine response, focusing on the impact of common polymorphisms within two genes, CYP1A2 and ADORA2A.
|
28853006 |
2018 |
|
Anxiety
|
0.070 |
Biomarker
|
disease |
BEFREE |
CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety.
|
30248915 |
2018 |
|
Autistic Disorder
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the influence of adenosine A2A receptor activity on C-C and C-X-C chemokine receptors involved in autism in the BTBR mouse model.
|
28421534 |
2018 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy.
|
29761007 |
2018 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
Interestingly, paired-pulse depression was similarly sensitive to disruption by ATP P2Y and adenosine A2A receptor antagonists.
|
29277734 |
2018 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, paired-pulse depression was similarly sensitive to disruption by ATP P2Y and adenosine A2A receptor antagonists.
|
29277734 |
2018 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy.
|
29761007 |
2018 |