|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study partially replicates recent findings of a CRHR1 by childhood adversity interaction with regard to adult depression highlighting the subjective characteristics of the environmental pathogen that is operative in this interaction.
|
22748421 |
2013 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD).
|
23962971 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD).
|
23962971 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking.
|
22957021 |
2012 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
|
22573456 |
2012 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results provide support for an association of CRHR1 and CRHR2 with MDD and PD.
|
22467522 |
2012 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRHR1 was genotyped in 83 controls and a preliminary sample of 16 unmedicated patients with MDD who completed a functional magnetic resonance imaging scan while viewing blocks of positive, negative, and neutral words.
|
22378896 |
2012 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These results provide support for an association of CRHR1 and CRHR2 with MDD and PD.
|
22467522 |
2012 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
|
20860876 |
2011 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk.
|
21998007 |
2011 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775).
|
22194899 |
2011 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although we did not replicate the specific interaction of abuse and the TAT-haplotype of the CRHR1 gene we confirmed the relevance of an interplay between variants within the CRHR1 gene and childhood adversities in the modulation of depression in adults.
|
20957648 |
2010 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R).
|
20383137 |
2010 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings.
|
19548263 |
2010 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression.
|
19736354 |
2009 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic-pituitary-adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress.
|
19596121 |
2009 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To comprehensively map the genetic variation in CRHR1 in relation to suicidality and depression, as a follow-up to our initial report on SNP rs4792887, we analyzed six new single nucleotide polymorphisms (SNPs), in an extended sample of family trios (n = 672) with suicide attempter offspring, by using family-based association tests.
|
19220485 |
2009 |