|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to alcohol dependence, we analysed two independent samples: a sample of adolescents, which consisted of individuals from the 'Mannheim Study of Risk Children' (MARC), who had little previous exposure to alcohol, and a sample of alcohol-dependent adults, who met DSM-IV criteria of alcohol dependence.
|
16550213 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits, and alcohol use in adolescents and young adults at high risk for alcoholism.
|
24623788 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that polymorphisms in the CRHR 1 gene are not major risk factors for the development of alcohol dependence in persons of European ancestry.
|
15992556 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study extends the literature on the interplay between CRHR1 variation and alcoholism, in the context of exposure to traumatic stress.
|
23473364 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ongoing clinical trials with pexacerfont and verucerfont in moderately to highly severe dependent anxious alcoholics may yield insight as to the role of CRF(1) receptor antagonists in a personalized medicine approach to treat drug or alcohol dependence.
|
23294766 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence.
|
23220399 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression.
|
25802844 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CRHR1 may be involved in modulating the P3 component of the ERP during information processing and in vulnerability to alcoholism.
|
20374216 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is concluded from the findings of the studies discussed in this review that CRF has a central role in the modulation of the stress response and that genetic variations in CRF or CRF1 may confer a susceptibility to alcoholism which is, in part, mediated by life stressors.
|
19409922 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits, and alcohol use in adolescents and young adults at high risk for alcoholism.
|
24623788 |
2014 |
|
Allodynia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Role of CRF1 receptor in post-incisional plasma extravasation and nociceptive responses in mice.
|
28434951 |
2017 |
|
Alopecia, Male Pattern
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
|
22693459 |
2012 |
|
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For HPA involvement, a CRHR1 haplotype with MAPT was described, but further association of only HSD11B1 with LOAD found; however, association of FKBP1 and NC3R1 polymorphisms was documented in support of stress influence to LOAD.
|
30386171 |
2018 |
|
Alzheimer's Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
CRFR1 antagonism presents a viable disease-modifying therapy for AD, recommending its advancement to early-phase human safety trials.
|
26555315 |
2016 |
|
Alzheimer's Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our previous work suggests that treating AD transgenic mice the type-1 corticotropin-releasing factor receptor (CRFR1) antagonist, R121919, to reduce stress signaling, prevented onset of cognitive impairment, synaptic/dendritic loss and Aβ plaque accumulation.
|
28750017 |
2017 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that isolation stress increases corticosterone levels and GR and CRFR1 expression in conjunction with increases in brain tissue Abeta levels and Abeta plaque deposition in the Tg2576 mouse model of AD.
|
18571864 |
2008 |
|
Alzheimer's Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
In summary, our results suggest that interference of CRFR1 in an AD model is tolerable and is efficacious in impacting Aβ neuropathology.
|
25697705 |
2015 |
|
Alzheimer's Disease
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
These stress effects were reversed by blocking the activation of the hypothalamus-pituitary-adrenal gland axis with the corticotropin-releasing factor receptor antagonist NBI 27914, further suggesting that over-activation of the hypothalamic-pituitary-adrenal axis is required for stress-enhanced AD-like pathogenesis.
|
19012747 |
2009 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we developed a novel transgenic mouse to determine whether partial or complete ablation of CRFR1 was feasible in an AD transgenic model and whether this type of treatment could impact Aβ pathology.
|
25697705 |
2015 |
|
anaphylaxis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We have previously demonstrated that activation of the corticotropin-releasing factor (CRF) system potentiates MC degranulation responses during IgE-mediated anaphylaxis and psychological stress through corticotropin-releasing factor receptor subtype 1 (CRF<sub>1</sub>) expressed on MCs.
|
30439403 |
2019 |
|
Anhedonia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning.
|
21917807 |
2011 |
|
Anhedonia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Using an intermediate phenotypic neurogenetics approach, we assessed how stress and CRHR1 genetic variation (rs12938031) influence reward learning, an important component of anhedonia.
|
21917807 |
2011 |
|
Anorexia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Corticotropin-releasing factor-1 receptors in the basolateral amygdala mediate stress-induced anorexia.
|
16420149 |
2005 |
|
Antisocial behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors.
|
29772307 |
2018 |