CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Higher CRP was not associated with depression, and it independently predicted mortality (OR = 1.92, p = 0.030). 27384414 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE The odds of depression increased by 2% (95% CI = 1-4%) for every unit (mg/l) increase of CRP and nearly doubled for men with CRP > or = 3 mg/l vs <1 mg/l [odds ratio (OR) = 1.95, 95% confidence interval (CI) = 1.27-2.98]. 19433520 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Regression models adjusting for demographic and lifestyle-related covariates showed no direct association of CESD depression scores with CRP. 19796676 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE We aimed to investigate the association between CRP and overall depression severity including specific depressive symptoms and to examine potential gender differences. 28257825 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 AlteredExpression disease BEFREE Higher baseline CRP levels were associated lower depression severity (correlation coefficient=-0.63) with bupropion-SSRI combination but not with SSRI monotherapy (correlation coefficient=0.40).The overall remission rate was 41.5%. 28187400 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE The significant relationship between CRP and depression in the underweight group suggested that not only obesity but also a low BMI could explain a substantial portion of the inflammation-depression link. 28128231 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms. 26846364 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Conclusions The level of CRP plays a role of biomarker to differentiate between MDD and BD II depression in both their depressed and euthymic state. 26895280 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE The factors which influenced cardiogenic shock and death from any cause were: heart rate at admission, diastolic blood pressure at admission, C-reactive protein (CRP) concentration at admission, chest pain at admission, ST-segment depression in the electrocardiography at admission, and ejection fraction at admission. 29979617 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups. 31823093 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE A total of 126 patients with PsA were included and the following variables were assessed: Tender joint count (TJC), swollen joint count (SJC), patient's global assessment, physician's global assessment, pain, extra-articular manifestations, Psoriasis Area and Severity Index, Health Assessment Questionnaire, fatigue, Short Form-36, psoriatic quality of life, Hospital Anxiety and Depression Scale and C-reactive protein (CRP). 30426235 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Markers of impaired cellular immunity (decreased natural killer cell cytotoxicity) and inflammation (elevated IL-6, TNFα, and CRP) have been associated with depression. 20955778 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Although previous data indicate that dyadic coping is associated with Hypothalamic-Pituitary-Adrenal (HPA-axis and C-reactive protein (CRP) separately, no study has reported on the ratio between these two systems and dyadic coping, despite this index of physiological homeostasis being associated with physical health and depression. 31479683 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE The effect between depression and CRP was small, but highly significant across all stages of the meta-analysis (p < 0.01). 29928963 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 GeneticVariation disease BEFREE Controlling for inflammatory activity at BD1, depression at BD1, demographics and the time between assessments, increases in interleukin-6 (IL-6; b = 0.878, p = .007) and C-reactive protein (CRP; b = 0.252, p = .024) from BD1 to BD2 interacted with recent stressful life events before BD1 to predict severity of depressive symptoms at BD2. 30822466 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE This indicates that CRP per se is not a causal risk factor for depression. 24246360 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE This study explored the relation between baseline anxiety as measured by the Beck Anxiety Inventory and depression as measured by the Beck Depression Inventory-II and baseline serum c-reactive protein (CRP) in a cross-sectional sample of 100 participants [mean (SD) age 57.8 (7.7) years; 64% female] with obesity [mean (SD) body mass index, BMI 37.3 (5.5) kg/m<sup>2</sup> ] enrolled in a clinical trial for pharmacological weight loss. 28000423 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU). 31319037 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE A complete clinical assessment, assessment of vascular risk factors, blood sample for the evaluation of serum CRP was obtained, and baseline depression severity was measured on Hamilton Depression Rating Scale (HDRS). 30581212 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized crossover study examined serial assessments of two endotoxin biomarkers, LPS-binding protein (LBP) and soluble CD14 (sCD14), as well as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) during two separate 9.5 h visits. 30098513 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE HOMA2IR and insulin were predicted by diagnosis (increased in MS), age and body mass index (BMI); AIP by diagnosis, sex, BMI, CRP, and uric acid; triglycerides by diagnosis (higher in MS without depression), age, BMI and uric acid; ferritin by diagnosis (higher in MS), sex, CRP, and albumin; and iron by albumin. 28152396 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE In this large study of the relationship between CRP and posttraumatic stress pathology, we demonstrated an association between systemic inflammation and stress pathology (PTSD; trending with depression), which remained after adjusting for potentially confounding variables. 28135632 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Receiver operating characteristic analysis indicated that CRP had moderate predictive accuracy in identifying elevated depression (area under the curve = 0.74). 30521079 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 Biomarker disease BEFREE Further, the significant association between OC use and reduced KynA as well as increased CRP, could conceivably partially account for the epidemiological association between OC use and depression. 28867283 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.100 AlteredExpression disease BEFREE Our findings raise new evidence for the relationship between circulating CRP level and depression occurrence. 29340226 2017