Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU).
|
31319037 |
2020 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
A complete clinical assessment, assessment of vascular risk factors, blood sample for the evaluation of serum CRP was obtained, and baseline depression severity was measured on Hamilton Depression Rating Scale (HDRS).
|
30581212 |
2020 |
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.
|
31707310 |
2020 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
|
30854996 |
2020 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
|
31823093 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 126 patients with PsA were included and the following variables were assessed: Tender joint count (TJC), swollen joint count (SJC), patient's global assessment, physician's global assessment, pain, extra-articular manifestations, Psoriasis Area and Severity Index, Health Assessment Questionnaire, fatigue, Short Form-36, psoriatic quality of life, Hospital Anxiety and Depression Scale and C-reactive protein (CRP).
|
30426235 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although previous data indicate that dyadic coping is associated with Hypothalamic-Pituitary-Adrenal (HPA-axis and C-reactive protein (CRP) separately, no study has reported on the ratio between these two systems and dyadic coping, despite this index of physiological homeostasis being associated with physical health and depression.
|
31479683 |
2019 |
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Controlling for inflammatory activity at BD1, depression at BD1, demographics and the time between assessments, increases in interleukin-6 (IL-6; b = 0.878, p = .007) and C-reactive protein (CRP; b = 0.252, p = .024) from BD1 to BD2 interacted with recent stressful life events before BD1 to predict severity of depressive symptoms at BD2.
|
30822466 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic analysis indicated that CRP had moderate predictive accuracy in identifying elevated depression (area under the curve = 0.74).
|
30521079 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey.
|
30760746 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to examine the serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients to find out their association with depression.
|
30899619 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The associations between baseline log CRP and depression response and remission were also assessed.
|
29654412 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The depression sum-score was related to both IL-6 and CRP before, and only to IL-6 after covariate adjustment.
|
31615595 |
2019 |
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These effects were fully attenuated by five serum proteins: AGE: Insulin-like Growth Factor-Binding Protein 2 (IGF-BP2), Epidermal Growth Factor Receptor 1 (EGFR); Depression: Resistin; Gender: Thrombopoeitin (THPO); APOE: C-Reactive Protein (CRP).
|
31665233 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
When stratifying by zygosity, significant associations from IL-6 to depression were only seen in monozygotic twins, but associations from depression to CRP were more robust in dizygotic twins, which implies that genetic factors may play a role in this association.
|
30394311 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, C-reactive protein was not associated with current depression in cross-sectional and longitudinal analyses.
|
30819515 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
After additionally controlling for physical activity, elevated WBC count (p = 0.002) and decreased levels of urine cortisol (p = 0.05) remained significant predictors of PTSD course, and elevated WBC count (p = 0.001), CRP (p = 0.03), and fibrinogen (p = 0.02) remained significant predictors of depression course.
|
30389462 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [β = 0.13, p = 0.007; β = 0.14, p = 0.007], and with two inflammatory markers: CRP [β = 0.14, p = 0.007; β = 0.16, p = 0.007] and OPG [β = 0.14, p = 0.007; β = 0.11, p = 0.007].
|
29721726 |
2019 |
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inflammation is associated with depression, especially in women, and levels of C-reactive protein (CRP) and interleukin (IL)-6 predict response to antidepressant medications.
|
29489077 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
No significant correlation was found between severity of depression and serum concentration of CRP, BDNF, and IL-2 in both the groups.
|
30405261 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of elevated CRP (>1 mg/L) in depression was 58% (95% CI 47-69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI 1.18-1.82).
|
31258105 |
2019 |
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Participants with a high CRP levels had a significantly higher rate of depression than did those with a low hs-CRP levels (25.1% vs. 19.8%, p = 0.007).
|
31377557 |
2019 |
Depressive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Removing the interaction term, CES-D trajectory was associated with inflammation: higher levels of high-sensitivity C-reactive protein were observed in the subthreshold (β = 0.57, p = .004) and increasing depressive symptoms (β = 1.36, p < .001) trajectories compared with the no depression trajectory.
|
30624288 |
2019 |
Depressive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion.
|
31711279 |
2019 |
Depressive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6, CRP and triglycerides are likely to be causally linked with depression, so could be targets for treatment and prevention of depression.
|
30886334 |
2019 |