|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiple regression analyses showed independent associations of CRP with diagnosis of sepsis, and CRP and lactate with mortality.
|
29176018 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We specified PCT and CRP cut-off values with high PPV and NPV for revealing the presence of bacterial infection and sepsis in HD patients.
|
29717808 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study revealed the superiority of colistin-meropenem combination therapy over colistin monotherapy in the treatment of MDR K. pneumoniae-induced HAP or VAP and highlights the advantage of procalcitonin over CRP as a marker for eradication of sepsis and suspension of therapy.
|
30010061 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The APACHE II score was calculated, and their peripheral venous blood SAA, NO and CRP levels were evaluated on days 1, 3, and 7 after sepsis was diagnosed.
|
30048858 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The values of SAA, IgA, IgM, WBC, IL-6, and CRP in septicemia patients were 0.700, 0.428, 0.689, 0.682, 0.891, and 0.853, respectively.
|
29129626 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, IL-6, CRP and WBC showed no significant difference between the SIRS group and the sepsis group.
|
29760745 |
2018 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sepsis-3 (subdistribution HR (sHR)=5.47; p=0.006), qSOFA (sHR=1.99; p=0.020), Chronic Liver Failure Consortium Acute Decompensation score (sHR=1.05; p=0.001) and C reactive protein (sHR=1.01;p=0.034) were found to be independent predictors of in-hospital mortality.
|
28860348 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dynamic monitoring of CRP and PCT has important clinical significance in predicting the prognosis of patients with sepsis.
|
29731821 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The serum levels of high mobility group box 1 and C-reactive protein were increased in sepsis patients compared with those in healthy individuals.
|
30186449 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LASSO regression identified CRP and HLA-DRA mRNA as being repeatedly associated with sepsis, and no model performed better than CRP alone (ROC-AUC 0.76 [0.68-0.84]).
|
29959455 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum levels of C-reactive protein (CRP) as biomarker endpoint and recovery of sepsis as clinical endpoint were used to compare treatment responses between groups.
|
30012383 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A total of 250 critically ill pediatric patients diagnosed with sepsis were retrospectively analyzed to identify routinely measured predictors for in-hospital mortality at the peak level of C-reactive protein.
|
30446841 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concentrations of these biomarkers in function of sepsis severity (sepsis n = 94 and septic shock n = 21) and outcome (lethal n = 40, recovery n = 75) were tested, as well as correlations with APACHE II and SOFA scores, immunoglobulins, complement, PCT and CRP concentrations.
|
30142533 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
At T0, combining the CBC and the CRP had the highest sensitivity of 66% (95% confidence interval [CI], 58-73) compared to both individual tests for predicting late onset sepsis.
|
29382319 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that the sensitivity of sMR to predict mortality [area under curve (AUC) = 0.77] exceeded the sensitivity of procalcitonin (PCT, AUC = 0.63), C-reactive protein (CRP, AUC = 0.61) and the macrophage soluble receptor, CD163 (sCD163, AUC = 0.74), while it was less accurate to predict diagnosis of sepsis [AUC(sMR) = 0.69 vs. AUC(PCT) = 0.79, AUC(CRP) = 0.71 and AUC(sCD163) = 0.66].
|
29383956 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers).
|
28135842 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Investigated variables associated with increased risk for the presence of bacteria on synovial fluid included features of sepsis (P < 0.001), joint-restricted range of motion (P = 0.048), elevated C-reactive protein (P < 0.001) and elevated total leukocyte count on synovial fluid (P < 0.001).
|
29756282 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CSF protein levels were 0.89 g/l (SD 0.37) in neonates without fever or elevated CRP (n = 26) and not significantly different from neonates with possible sepsis (n = 218) with 0.92 g/l (SD 0.40).
|
29540199 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Procalcitonin and CRP were not significantly different ( P > .06) between patients with sepsis and nonseptic patients.
|
30411670 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available.
|
30547887 |
2018 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS Our study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis.
|
29379005 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The value of CRP was not predictive of sepsis at either time points.
|
28824010 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
First-day GSN also differentiated sepsis from non-sepsis (AUC: 0.88) similarly to C-reactive protein (AUC: 0.80) but was slightly inferior to procalcitonin (PCT) (AUC: 0.98) with a cutoff value of GSN at 22.29 mg/L (sensitivity: 83.3%; specificity: 86.2%).
|
29320362 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found a significant relationship between interleukin-33 and C-reactive protein and between interleukin-6 and C-reactive protein on the first day of sepsis.
|
30207217 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis.
|
30068303 |
2018 |