|
Adenocarcinoma of lung (disorder)
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Colorectal Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis.
|
24947187 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis.
|
24947187 |
2014 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
CSNK1E was upregulated in CRC (p = 0.02).
|
27492458 |
2016 |
|
Polycystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.
|
29537311 |
2018 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample.
|
30445897 |
2018 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Casein kinase 1 epsilon (<i>CK1ε</i>) gene expression plays a role in numerous cancers, and the knockdown of <i>CK1ε</i> induces tumor cell-selective cytotoxicity.
|
31602258 |
2019 |
|
Epileptic encephalopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A de novo pathogenic CSNK1E mutation identified by exome sequencing in family trios with epileptic encephalopathy.
|
30488659 |
2019 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with BP (P = 0.00000172).
|
18228528 |
2008 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with BP (P = 0.00000172).
|
18228528 |
2008 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
An Inhibitor of Casein Kinase 1ε/δ (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation.
|
29989105 |
2018 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse.
|
22743604 |
2012 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
As CK1ε is highly expressed in breast tumors, these findings offer an initial rationale to explore CK1ε blockade as a therapeutic strategy to treat cancers driven by deregulated mRNA translation.
|
24247720 |
2014 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.
|
22367616 |
2012 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.
|
22367616 |
2012 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
BIRC2 and CSNK1E were respective hub genes of RA- and OA-specific PPI network.
|
30834598 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
BIRC2 and CSNK1E were respective hub genes of RA- and OA-specific PPI network.
|
30834598 |
2019 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both CSNK1E and STXBP1 showed a closer coexpression relationship with epilepsy candidate genes beyond that expected by chance.
|
30488659 |
2019 |
|
Motor neuron atrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DDX3 and CK1ε positive cells were mainly distributed in the anterior horn of spinal cord and co-localized with neurons not with glial cells, suggesting that the altered expression of DDX3 and CK1ε was closely related to motor neuron degeneration of ALS.
|
29118923 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DDX3 and CK1ε positive cells were mainly distributed in the anterior horn of spinal cord and co-localized with neurons not with glial cells, suggesting that the altered expression of DDX3 and CK1ε was closely related to motor neuron degeneration of ALS.
|
29118923 |
2017 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Deregulation of casein kinase 1 epsilon (CK1ε) is involved in the development of multiple pathological disorders such as cancer, however the function and molecular mechanism of CK1εin cancer are still unclear.
|
26122218 |
2015 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Deregulation of casein kinase 1 epsilon (CK1ε) is involved in the development of multiple pathological disorders such as cancer, however the function and molecular mechanism of CK1εin cancer are still unclear.
|
26122218 |
2015 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Expression of the Clock gene and the CKIε gene in cancer tissue were significantly higher compared to that in adjacent normal mucosa.
|
21380491 |
2011 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Expression of the Clock gene and the CKIε gene in cancer tissue were significantly higher compared to that in adjacent normal mucosa.
|
21380491 |
2011 |